CAY10415
- CAS No.
- 146062-49-9
- Chemical Name:
- CAY10415
- Synonyms
- 0160;CS-1615;CAY10415;MSDC-0160;MSDC-Mitoglitazone;MSDC-0160(CAY10415);CAY10415 MSDC-0160;CAY10415 Exclusive;CAY10415 (Mitoglitazone)
- CBNumber:
- CB92590409
- Molecular Formula:
- C19H18N2O4S
- Molecular Weight:
- 370.42
- MDL Number:
- MFCD00916084
- MOL File:
- 146062-49-9.mol
| Boiling point | 623.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.315±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | ≥37 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| form | A crystalline solid |
| pka | 6.32±0.50(Predicted) |
| FDA UNII | 29I7RP18RG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
CAY10415 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1884 | Mitoglitazone ≥98% (HPLC) | 146062-49-9 | 5MG | $102 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1884 | Mitoglitazone ≥98% (HPLC) | 146062-49-9 | 25MG | $330 | 2023-06-20 | Buy |
| Cayman Chemical | 71748 | CAY10415 ≥98% | 146062-49-9 | 1mg | $39 | 2024-03-01 | Buy |
| Cayman Chemical | 71748 | CAY10415 ≥98% | 146062-49-9 | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 71748 | CAY10415 ≥98% | 146062-49-9 | 10mg | $189 | 2024-03-01 | Buy |
CAY10415 Chemical Properties,Uses,Production
Uses
CAY10415 is used to study blood glucose levels and rates of insulin-stimulated lipogenesis.
Definition
ChEBI: 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]thiazolidine-2,4-dione is an aromatic ether.
Biological Activity
msdc-0160 is a prototype mtot-modulating insulin sensitizer [1].msdc-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator–activated receptor-γ (ppar-γ)-dependent side effects. co-incubation of islets with msdc-0160 and igf-1 reduces the resistance of insulin-signaling pathway and preserves insulin content. msdc-0160 at 50μm alone also prevents the loss of insulin content significantly. besides that, treatment of msdc-0160 increases the phosphorylation of ampk and reduces mtor phosphorylation. moreover, msdc-0160 is also found to display pro-survival effects in human islets via reducing the level of cleaved caspase-3 and increasing the expression of apoptosis-related genes such as bcl2. in addition, msdc-0160 exerts prevention of nuclear translocation with β-catenin localized on the cell membrane or cytoplasm in human β-cells [1].
References
[1] rohatgi n, aly h, marshall c a, et al. novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. plos one, 2013, 8(5): e62012.
CAY10415 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |