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DG 051 (HCl salt)

DG 051 (HCl salt) Structure
DG 051 (HCl salt) structure
CAS No.
929915-58-2
Chemical Name:
DG 051 (HCl salt)
Synonyms
DG051;DG051 (DG-051;DG 051 (HCl salt);DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051;(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride;4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
CBNumber:
CB92627754
Molecular Formula:
C21H25Cl2NO4
Molecular Weight:
426.3335
MDL Number:
MFCD18251532
MOL File:
929915-58-2.mol
Last updated:2023-06-08 09:03:09
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DG 051 (HCl salt) Properties

storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 2 mg/ml
FDA UNII 28B7Y5Y8EF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319
Precautionary statements  P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
NFPA 704
3
2 0

DG 051 (HCl salt) price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21688 DG-051 ≥98% 929915-58-2 1mg $32 2024-03-01 Buy
Cayman Chemical 21688 DG-051 ≥98% 929915-58-2 5mg $139 2024-03-01 Buy
Cayman Chemical 21688 DG-051 ≥98% 929915-58-2 10mg $243 2024-03-01 Buy
Cayman Chemical 21688 DG-051 ≥98% 929915-58-2 25mg $533 2024-03-01 Buy
TRC C381365 (2S)​-2-​[[4-​(4-Chlorophenoxy)​phenoxy]​methyl]​-1-​pyrrolidinebutanoicAcidHydrochloride 929915-58-2 100mg $1365 2021-12-16 Buy
Product number Packaging Price Buy
21688 1mg $32 Buy
21688 5mg $139 Buy
21688 10mg $243 Buy
21688 25mg $533 Buy
C381365 100mg $1365 Buy

DG 051 (HCl salt) Chemical Properties,Uses,Production

Description

DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 . However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.

Uses

(2S)?-2-?[[4-?(4-Chlorophenoxy)?phenoxy]?methyl]?-1-?pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers.

DG 051 (HCl salt) Preparation Products And Raw materials

Raw materials

Preparation Products

DG 051 (HCl salt) Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai ChuangYan Chemical Technology Co., Ltd. 021-11111111 11111111111 546919421@qq.com China 2992 55
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Musechem +1-800-259-7612 info@musechem.com United States 4662 60
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Supplier Advantage
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
Aladdin Scientific 		58
Shanghai ChuangYan Chemical Technology Co., Ltd. 55
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Musechem 60
Fan De(Beijing) Biotechnology Co., Ltd. 58
DC Chemicals 58

View Lastest Price from DG 051 (HCl salt) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DG 051 (HCl salt) pictures 2019-07-06 DG 051 (HCl salt)
929915-58-2
 US $1.00 / KG 1KG 96% 500kg Career Henan Chemical Co
DG 051 (HCl salt) 4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride DG051 (2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride DG051 (DG-051 DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051 929915-58-2