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UNC0321

UNC0321 Structure
UNC0321 structure
CAS No.
1238673-32-9
Chemical Name:
UNC0321
Synonyms
UNC0321;UNC0321(UNC-0321);UNC 0321; UNC-0321; UNC0321; UNC-0321;H3K9me2,SAR,PKMT,Histone Methyltransferase,H3K9,quinazoline,inhibit,K373,UNC-0321,p53,UNC0321,UNC 0321,G9a,GLP,Inhibitor;7-(2-(2-(diMethylaMino)ethoxy)ethoxy)-6-Methoxy-2-(4-Methyl-1,4-diazepan-1-yl)-N-(1-Methylpiperidin-4-yl)quinazolin-4-aMine;7-[2-[2-(Dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine;4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-
CBNumber:
CB92628498
Molecular Formula:
C27H45N7O3
Molecular Weight:
515.69
MDL Number:
MFCD18251565
MOL File:
1238673-32-9.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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UNC0321 Properties

Boiling point 664.7±65.0 °C(Predicted)
Density 1.150±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 31 mg/mL (60.11 mM)
pka 9.34±0.70(Predicted)
form Powder

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

UNC0321 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 377024 UNC0321 1238673-32-9 50mg $1011 2021-12-16 Buy
American Custom Chemicals Corporation INB0001553 UNC-0321 95.00% 1238673-32-9 5MG $505.8 2021-12-16 Buy
ChemScene CS-2211 UNC0321 >98.0% 1238673-32-9 5mg $116 2021-12-16 Buy
ChemScene CS-2211 UNC0321 >98.0% 1238673-32-9 10mg $180 2021-12-16 Buy
ChemScene CS-2211 UNC0321 >98.0% 1238673-32-9 50mg $840 2021-12-16 Buy
Product number Packaging Price Buy
377024 50mg $1011 Buy
INB0001553 5MG $505.8 Buy
CS-2211 5mg $116 Buy
CS-2211 10mg $180 Buy
CS-2211 50mg $840 Buy

UNC0321 Chemical Properties,Uses,Production

Definition

ChEBI: 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine is a member of quinazolines.

Biological Activity

UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with Ki of 63 pM and IC50 of 6-9 nM.It also inhibits GLP with IC50 values of 15-23 nM.UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.

in vitro

In G9a ECSD and CLOT assays, the IC 50 values of 9 nM and 6 nM for UNC0321 (Compound 29), respectively. In GLP ECSD and CLOT assays, the IC 50 values of 15 nM and 23 nM for UNC0321, respectively.
UNC0321 (Compound 3) reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM.

target

G9a

63 pM (Ki)

G9a

6-9 nM (IC 50 )

GLP

15-23 nM (IC 50 )

UNC0321 Preparation Products And Raw materials

Raw materials

Preparation Products

UNC0321 Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 		0431-80514535 13634302652 Extension@chemextension.com CHINA 967 58
Shanghai Daeyeon Chemicals Co., Ltd 		021-64478606 +8615900664856 daeyeon001@vip.163.com China 2062 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 		58
Shanghai Daeyeon Chemicals Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Amadis Chemical Company Limited 		58

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1of4

UNC0321 7-(2-(2-(diMethylaMino)ethoxy)ethoxy)-6-Methoxy-2-(4-Methyl-1,4-diazepan-1-yl)-N-(1-Methylpiperidin-4-yl)quinazolin-4-aMine 7-[2-[2-(Dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine UNC0321(UNC-0321) UNC 0321; UNC-0321; UNC0321; UNC-0321 4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)- H3K9me2,SAR,PKMT,Histone Methyltransferase,H3K9,quinazoline,inhibit,K373,UNC-0321,p53,UNC0321,UNC 0321,G9a,GLP,Inhibitor 1238673-32-9 C27H45N7O3