Bexagliflozin
- CAS No.
- 1118567-05-7
- Chemical Name:
- Bexagliflozin
- Synonyms
- CS-250;CS-2165;EGT1442;THR1442;THR 1442;THR-1442;EGT0001442;EGT-0001442;EGT 0001442;Bexgliflozin
- CBNumber:
- CB92650633
- Molecular Formula:
- C24H29ClO7
- Molecular Weight:
- 464.94
- MDL Number:
- MFCD28100944
- MOL File:
- 1118567-05-7.mol
- MSDS File:
- SDS
Boiling point | 671.0±55.0 °C(Predicted) |
---|---|
Density | 1.41 |
storage temp. | Store at -20°C |
solubility | DMSO:100.0(Max Conc. mg/mL);215.08(Max Conc. mM) |
form | A crystalline solid |
pka | 13.23±0.70(Predicted) |
InChIKey | BTCRKOKVYTVOLU-IZSIRFNDNA-N |
SMILES | [C@H]1(C2C=C(CC3C=CC(OCCOC4CC4)=CC=3)C(Cl)=CC=2)[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:0,22,24,26,28,r| |
FDA UNII | EY00JF42FV |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
NFPA 704 |
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Bexagliflozin price More Price(17)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21359 | EGT-1442 ≥95% | 1118567-05-7 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 21359 | EGT-1442 ≥95% | 1118567-05-7 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 21359 | EGT-1442 ≥95% | 1118567-05-7 | 10mg | $243 | 2024-03-01 | Buy |
Cayman Chemical | 21359 | EGT-1442 ≥95% | 1118567-05-7 | 25mg | $533 | 2024-03-01 | Buy |
TRC | B336785 | Bexagliflozin3 | 1118567-05-7 | 10mg | $310 | 2021-12-16 | Buy |
Bexagliflozin Chemical Properties,Uses,Production
Description
EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively. It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.
Uses
Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients.
Definition
ChEBI: Bexagliflozin is a C-glycosyl comprising of beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl group. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a sodium-glucose transport protein subtype 2 inhibitor, a hypoglycemic agent and an antihypertensive agent. It is a C-glycosyl compound, an aromatic ether, a member of monochlorobenzenes, a diether and a member of cyclopropanes.
Mechanism of action
Bexagliflozin is a highly selective inhibitor of sodium-glucose cotransporter protein 2 (SGLT2), which cotransports sodium and glucose from the filtrate to the epithelium of the proximal renal tubule, thereby lowering the tubular glucose reabsorption threshold, reducing renal glucose reabsorption, and increasing urinary glucose excretion without affecting insulin levels.
Bexagliflozin Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 | info@millionpharm.com | China | 205 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19536 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13349 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from Bexagliflozin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-23 | Bexagliflozin
1118567-05-7
|
US $2.00 / kg | 0.10000000149011612kg | 99% | 200KG | Jinan Million Pharmaceutical Co., Ltd | ||
2024-02-23 | Bexagliflozin
1118567-05-7
|
US $380.00 / g | 1g | 99 | 50 Kg | R&D Scientific Inc. | ||
2019-07-06 | EGT1442
1118567-05-7
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
- Bexagliflozin
1118567-05-7
- US $2.00 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
- Bexagliflozin
1118567-05-7
- US $380.00 / g
- 99
- R&D Scientific Inc.
- EGT1442
1118567-05-7
- US $2.00 / kg
- 99%
- Career Henan Chemical Co