- CAS No.
- Chemical Name:
- ERGOTAMINE TARTRATE
- Molecular Formula:
- Molecular Weight:
- MDL Number:
- MOL File:
|Melting point||~195 °C (dec.)(lit.)|
|alpha||D25 -125 to -155° (c = 0.4 in chloroform)|
|CAS DataBase Reference||379-79-3(CAS DataBase Reference)|
|EWG's Food Scores||2|
|Proposition 65 List||Ergotamine Tartrate|
|EPA Substance Registry System||Ergotamine tartrate (379-79-3)|
Risk and Safety Statements
|RIDADR||UN 1544 6.1/PG 1|
ERGOTAMINE TARTRATE price More Price(2)
|Manufacturer||Product number||Product description||CAS number||Packaging||Price||Updated||Buy|
ERGOTAMINE TARTRATE Chemical Properties,Uses,Production
Ergotamine and ergometrine belong to two kinds of ergot alkaloids. Ergot (Claviceps
purpurea, 麦角) is the sclerotium of ergot fungus that grows in the rye and related
cereal and forage plants. The ergot is grown in the northeast and north China and
Xinjiang, Jiangsu, Zhejiang, Sichuan, and other places. At present, the method of
growth of ergot is inoculation cultivation.
Traditional Chinese medicine believes that ergot is tasteless, tepid, toxic, liver meridian, and kidney meridian. The traditional usage of ergot is oral administration of extractum, 2–4 ml each time, daily amount of 6–8 ml. Its dosage forms also contain infusion, pills, injection, etc. Pharmacology of Chinese Medicine records ergot can be used for uterine contraction, uterine bleeding, and postpartum hemorrhage after delivery, incomplete recovery of uterus, retrogression, etc. The Plateau Chinese herbal medicine treatment manual records that ergot can cure migraine.
Ergotamine tartrate is a crystalline solid.
Appearance: White or slightly yellow fine crystalline powder with slight hygroscopicity. Solubility: Slightly soluble in water and ethanol, insoluble in ether and chloroform.
As a kind of traditional Chinese medicine, ergot was originally used for hemostasis and involution of uterus by stimulating the uterine muscle powerfully and persistently. After the modernization the traditional Chinese medicine was putting forward, by making several kinds of wild ergot into extractum, we found that all of them can promote the contraction of the rabbit uterus in vivo and in vitro. In isolated rabbit uterus, the effect of ergot on postpartum uterus and pregnant uterus was stronger than nonpregnant uterus. Among a variety of active ingredients in the ergot, ergonovine has the strongest effect on uterine, followed by ergotamine. Seventeen of the 131 strains of ergot derived from the host plants of our country are able to produce ergot alkaloids in wheat culture medium. Among the strains, Claviceps microcephala Ce-3 produces the most ergonovine. Therefore, it became the main bacteria used in the process of industrialization. The study suggested that ergotamine or ergot can block the a-adrenergic receptor, so that the pressor effect of adrenaline was reversed. They do not prevent the release of sympathetic mediators. It showed that the effect of ergotamine is similar to norepinephrine on the hypogastric nerve of guinea pig in vitro. Low dose of ergot can stimulate the brain (slow heart rate, breathing, convulsions, etc.) whereas high dose can cause deaths due to the delayed paralysis. In addition, it can enhance the sedative and hypnotic effects of barbiturates, morphine, and methadone.
diuretic, inhibits Na/K/2Cl carrier system
Ergometrine maleate is used in the form of extract tumor injection. As a uterotonic,
ergometrine maleate is mainly used for the prevention and treatment of uterine
bleeding caused by weak or poor uterine contraction after delivery or abortion, as
well as the incomplete recovery of postpartum uterus to accelerate the recovery of
Ergotamine tartrate is used for the treatment of migraine in the form of tablet and parenteral solution. It also can be used for other neurogenic headache as well.
Ergomar (Harvest);Ergostat (Parke-Davis); Wigrettes (Organon).
Powder or liquid forms available as drugs. Used in obstetrics and in the treatment of migraine headaches.
Air & Water Reactions
Insoluble in water.
ERGOTAMINE TARTRATE is sensitive to prolonged exposure to heat and light. . When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat [EPA, 1998].
High oral toxicity and a convulsant in humans.People with liver damage are at a greater risk.
When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat
1. The effect of uterus excitation
The effect of ergot on the uterine muscle is similar to the posterior pituitary preparation, which directly acts on the uterine muscle with more powerful and lasting effects. The pregnant uterus is more sensitive to ergot. Low dose of ergot has significant effects on the uterus of labor and new postpartum with severely tetanic contraction. The extracts from several kinds of wild ergot can promote the contraction and increase the tension of uterus in rabbit in vivo and in vitro . Among a variety of active ingredients in the ergot, ergonovine has the strongest effect on uterus, followed by ergotamine.
2. The effects on cardiovascular
In the isolated vascular experiment, ergotamine can cause the contraction of peripheral vascular smooth muscle and hypertension due to vasoconstriction and boost and eventually produce compensatory bradycardia. Ergot has less effect on the heart than blood vessels, but when the heart rate drops to a certain extent, it can enhance the cardiac contractility. High dose of ergotamine can damage vascular endothelial cells (the mechanism is unknown), leading to gangrene. Ergotine has the strongest effect on blood vessels, and ergometrine hardly affects blood pressure and damages to vascular endothelial cells. Ergotine can cause vasoconstriction and decrease the arterial pulse amplitude, which may be related to the therapeutic effect on migraine.
3. The effects on the nervous system
Ergotamine or ergot can block the a-adrenergic receptor and reverse the pressor effect of adrenaline without preventing the release of sympathetic neurotransmitters. Low dose of ergot stimulates the brain (slow down heart rate, breathing, convulsions, etc.), whereas high dose causes deaths due to the delayed paralysis. Ergotamine enhances the sedative and hypnotic effects of barbiturates, morphine, and methadone.
Ergonovine maleate is mainly used for the prevention and treatment of the weak
uterine contraction or poor contraction caused by uterine bleeding after delivery or
abortion. It is also used for incomplete recovery of postpartum uterus to accelerate
the recovery of the uterus.
Ergotamine tartrate is mainly used for the treatment of migraine by relieving the symptoms. However, it is only suitable for short-term usage of headache attacks, normally does not prevent migraine. The combination of ergotamine tartrate and caffeine is better than single oral administration with the mild side effects. It also can be used for other neurogenic headaches.
Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: hallucinations, dstorted perceptions, convulsions, nausea or vomiting, blood pressure elevation. Experimental reproductive effects. Human mutation data reported. Used in production of drugs of abuse. When heated to decomposition it emits toxic fumes of NOx. See also ERGOT.
(Toxicity evaluation); Suspected reprotoxic hazard, Suspected of causing genetic defects. The major uses of the ergot alkaloids fall into two categories: applications in obstetrics and treatment of migraine headaches. May be used in the production of “street” drugs
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required
It crystallises from MeOH. [Beilstein 25 III/IV 964.]
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, light, and heat
ERGOTAMINE TARTRATE Preparation Products And Raw materials
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