Nebentan
- CAS No.
- 403604-85-3
- Chemical Name:
- Nebentan
- Synonyms
- Nebentan;Nebentan free base;Ethenesulfonamide, N-[6-methoxy-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-2-phenyl-, (1E)-
- CBNumber:
- CB93034883
- Molecular Formula:
- C24H21N5O5S
- Molecular Weight:
- 491.52
- MDL Number:
- MFCD12912486
- MOL File:
- 403604-85-3.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO: 125 mg/mL (254.31 mM) |
| form | Solid |
| color | Light yellow to yellow |
| FDA UNII | IJ670B0H4A |
| Comptox DTXSID | DTXSID50193350 |
Nebentan price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DRA60485 | Nebentan | 403604-85-3 | 25mg | $1164.25 | 2026-06-04 | Buy |
| Biosynth | DRA60485 | Nebentan | 403604-85-3 | 50mg | $1620 | 2026-06-04 | Buy |
| ChemScene | CS-0027078 | Nebentan 99.67% | 403604-85-3 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0027078 | Nebentan 99.67% | 403604-85-3 | 10mg | $400 | 2021-12-16 | Buy |
| ChemScene | CS-0027078 | Nebentan 99.67% | 403604-85-3 | 25mg | $700 | 2021-12-16 | Buy |
Nebentan Chemical Properties, Uses, Production
Uses
Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].
in vivo
Nebentan (oral administration; 0.1-1 mg/kg; 4 weeks) significantly inhibits the progression of pulmonary hypertension and the development of right ventricular hypertrophy[2].Nebentan (oral administration; 1 mg/kg; 30 weeks) significantly ameliorates the poor survival rate of CHF rats, it markedly reduces the hypertrophy of both ventricles as well as pulmonary congestion[2].
IC 50
ETA: 0.697 nM (Ki); ETB: 569 nM (Ki)
References
[1] Hironori Yuyama, et al. Pharmacological Characterization of YM598, an Orally Active and Highly Potent Selective Endothelin ET(A) Receptor Antagonist. Eur J Pharmacol. 2003 Sep 30;478(1):61-71. DOI:10.1016/j.ejphar.2003.08.031
[2] Akira Fujimori, et al. YM598, an Orally Active ET(A) Receptor Antagonist, Ameliorates the Progression of Cardiopulmonary Changes and Both-Side Heart Failure in Rats With Cor Pulmonale and Myocardial Infarction. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S354-7. DOI:10.1097/01.fjc.0000166304.40937.0b
Nebentan Preparation Products And Raw materials
Raw materials
Preparation Products
Nebentan Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27756 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2377 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
