Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>FK-506-13C-d2

FK-506-13C-d2

FK-506-13C-d2 Structure
FK-506-13C-d2 structure
CAS No.
1356841-89-8
Chemical Name:
FK-506-13C-d2
Synonyms
TACROLIMUS (13C, 99%;Tacrolimus-13C;Tacrolimus-13C,D2 solution;Tacrolimus-13C, D2 (major);Methadone Hydrochloride Impurity 9;D2, 98%) 100 UG/ML IN ACETONITRILE;FK-506-13C,D2 (Major) (Tacrolimus) (>FK-506-13C,D2 (Major) (Tacrolimus)(>85%);Fujimycin-13C,D2 Tacrolimus-13C D2 FK-506-13C,D2;Tacrolimus 13CD2Q: What is Tacrolimus 13CD2 Q: What is the CAS Number of Tacrolimus 13CD2 Q: What is the storage condition of Tacrolimus 13CD2 Q: What are the applications of Tacrolimus 13CD2
CBNumber:
CB93141783
Molecular Formula:
C44H67D2NO12
Molecular Weight:
807.039483556
MDL Number:
MFCD31808174
MOL File:
1356841-89-8.mol
Last updated:2023-06-08 09:03:09
Request For Quotation

FK-506-13C-d2 Properties

storage temp. -70°C
solubility Chloroform: Slightly Soluble,Methanol: Slightly Soluble
form A solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
RIDADR  UN 1648 3 / PGII
NFPA 704
0
2 0

FK-506-13C-d2 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22178 FK-506-13C-d2 ≥99% deuterated forms (d1-d2); ≤1% d0 1356841-89-8 500 μg $520 2024-03-01 Buy
Cayman Chemical 22178 FK-506-13C-d2 ≥99% deuterated forms (d1-d2); ≤1% d0 1356841-89-8 1mg $863 2022-04-27 Buy
TRC F370002 FK-506-13C,D2(Major)(Tacrolimus)(>85%) 1356841-89-8 2.5mg $1850 2021-12-16 Buy
AK Scientific 2276EL (1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-(3,3-Dideuterio(313C)prop-2-enyl)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone 1356841-89-8 1mg $1178 2021-12-16 Buy
Product number Packaging Price Buy
22178 500 μg $520 Buy
22178 1mg $863 Buy
F370002 2.5mg $1850 Buy
2276EL 1mg $1178 Buy

FK-506-13C-d2 Chemical Properties,Uses,Production

Description

FK-506-13C-d2 contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation. The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors. In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors “leaky” to Ca2+.

Uses

A labelled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. A representative lot contained a distribution of 20% d-1, 40% d-2 and 20% d-3.

General Description

This stable-labeled internal standard is suited for quantitation of tacrolimus by LC/MS or GC/MS for clinical toxicology, therapeutic drug monitoring, or isotope dilution methods. Tacrolimus, also known as FK-506 or fujimycin, is an immunosuppressive drug marketed as Prograf, Advagraf, and Protopic usually used to prevent rejection of organ transplants and treatment of eczema. Use of a stable-labeled analog of tacrolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

FK-506-13C-d2 Preparation Products And Raw materials

Raw materials

Preparation Products

FK-506-13C-d2 Suppliers

Global( 24)Suppliers
Supplier Tel Email Country ProdList Advantage
SIMSON PHARMA LIMITED 		+91-8291074273 k.das@simsonpharma.com India 228 58
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656 greensnown@163.com China 9911 50
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Artis Biotech Co. Ltd. 19138486554 18582380095 sales@artisbio.com China 3066 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Cato Research Chemicals Inc. 020-81215950 4000-868-328 customer@uwalab.com United States 10413 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 rose.shi@synzest.com China 9287 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
QUALITY CONTROL SOLUTIONS LTD. 0755-66853366 15920483169 sales@chem-strong.com China 18810 58
Nanjing Shizhou Biology Technology Co.,Ltd 18351873721 helen.zhang@synzest.com China 8298 58
Supplier Advantage
SIMSON PHARMA LIMITED 		58
Shanghai Kewel Chemical Co., Ltd. 50
Sigma-Aldrich 80
Artis Biotech Co. Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Cato Research Chemicals Inc. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Energy Chemical 58
QUALITY CONTROL SOLUTIONS LTD. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

View Lastest Price from FK-506-13C-d2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tacrolimus-13C,D2 pictures 2023-05-27 Tacrolimus-13C,D2
1356841-89-8
 US $0.00-0.00 / mg 1mg 96% 50 mg Simson Pharma limited
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-13C-d2)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone Tacrolimus-13C Tacrolimus-13C,D2 solution TACROLIMUS (13C, 99% FK-506-13C,D2 (Major) (Tacrolimus) (> (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-13C-d2)- FK-506-13C,D2 (Major) (Tacrolimus)(>85%) D2, 98%) 100 UG/ML IN ACETONITRILE Tacrolimus 13CD2Q: What is Tacrolimus 13CD2 Q: What is the CAS Number of Tacrolimus 13CD2 Q: What is the storage condition of Tacrolimus 13CD2 Q: What are the applications of Tacrolimus 13CD2 Fujimycin-13C,D2 Tacrolimus-13C D2 FK-506-13C,D2 Methadone Hydrochloride Impurity 9 Tacrolimus-13C, D2 (major) 1356841-89-8 C44H67D2NO12 C43CH67D2NO12