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호스신 하이드로브로마이드
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호스신 하이드로브로마이드
Scopolamine hydrobromide
포뮬러 무게:
MOL 파일:

호스신 하이드로브로마이드 속성

195-199 °C (dry matter)(lit.)
D25 -24 to -26° (c = 5, calculated on anhydrous basis)
저장 조건
Store at RT
H2O: 50 mg/mL
물리적 상태
white to off-white
CAS 데이터베이스
114-49-8(CAS DataBase Reference)
Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta., 5.alpha.,7.beta.)-9-methyl- 3-oxa-9-azatricyclo[3.3.1. 02,4]non-7-yl ester, hydrobromide, (.alpha.S)-(114-49-8)


위험품 표기 Xn
위험 카페고리 넘버 22
안전지침서 36
유엔번호(UN No.) UN 1544 6.1/PG 1
WGK 독일 3
RTECS 번호 YM4550000
F 고인화성물질 3-8
독성 LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick)

호스신 하이드로브로마이드 MSDS

Scopolamine hydrobromide

호스신 하이드로브로마이드 C화학적 특성, 용도, 생산

화학적 성질

Off-White Solid


An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant


ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.


Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

일반 설명

Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.

일반 설명

Colorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.

공기와 물의 반응

Sensitive to air, light and moisture. Water soluble.

반응 프로필

Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .


Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.

생물학적 활성

Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Clinical Use

A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.

Purification Methods

The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]

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