InSolution H-89, Dihydrochloride - Calbiochem
- CAS No.
- Chemical Name:
- InSolution H-89, Dihydrochloride - Calbiochem
- Synonyms
- InSolution H-89, Dihydrochloride - Calbiochem
- CBNumber:
- CB94817360
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
InSolution H-89, Dihydrochloride - Calbiochem price More Price(1)
InSolution H-89, Dihydrochloride - Calbiochem Chemical Properties,Uses,Production
General Description
A solution of H-89, Dihydrochloride (Cat. No. 371963) in anhydrous DMSO. H-89 is a cell-permeable selective and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (Ki = 28.3 μM), Ca2+/calmodulin-dependent protein kinase II (Ki = 29.7 μM), protein kinase C (Ki = 31.7 μM), casein kinase I (Ki = 38.3 μM), and Rho Kinase II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 μM) by blocking the action of Rho kinase II.
Biochem/physiol Actions
Target Ki: 48 nM against protein kinase A
InSolution H-89, Dihydrochloride - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
InSolution H-89, Dihydrochloride - Calbiochem Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |