N-BOC-1,3-DIAMINO-2-PROPANOL
- CAS No.
- 144912-84-5
- Chemical Name:
- N-BOC-1,3-DIAMINO-2-PROPANOL
- Synonyms
- N-BOC-1,3-DIAMINO-2-PROPANOL;3-(Boc-amino)-1-amino-2-propanol;tert-butyl 3-amino-2-hydroxypropylcarbamate;ert-butylN-(3-amino-2-hydroxypropyl)carbamate;Tert-butyl n-(3-amino-2-hydroxypropyl)carbamate;Carbamic acid,N-(3-amino-2-hydroxypropyl)-, 1,1-dimethylethyl ester;Carbamic acid, (3-amino-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)
- CBNumber:
- CB9697654
- Molecular Formula:
- C8H18N2O3
- Molecular Weight:
- 190.24
- MDL Number:
- MFCD04118107
- MOL File:
- 144912-84-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-BOC-1,3-DIAMINO-2-PROPANOL 95.00% | CHM1050055 | 5MG | $497.19 |
| tert-butyl(3-amino-2-hydroxypropyl)carbamate | 2354AQ | 1g | $702.8 |
| tert-Butyl(3-amino-2-hydroxypropyl)carbamate 95% | A679901 | 5g | $1080 |
| tert-butyl(3-amino-2-hydroxypropyl)carbamate 95% | BB-4086959 | 10g | $1385 |
| tert-butylN-(3-amino-2-hydroxypropyl)carbamate 95%+ | CM327672 | 100g | $2187 |
| Melting point | 77-79 °C |
|---|---|
| Boiling point | 350.2±32.0 °C(Predicted) |
| Density | 1.090±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 12.22±0.46(Predicted) |
| Appearance | Off-white to light yellow Solid |
| optical activity | Consistent with structure |
| InChI | InChI=1S/C8H18N2O3/c1-8(2,3)13-7(12)10-5-6(11)4-9/h6,11H,4-5,9H2,1-3H3,(H,10,12) |
| InChIKey | LZNOKWJGNPKUSE-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NCC(O)CN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
N-BOC-1,3-DIAMINO-2-PROPANOL price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CHM1050055 | N-BOC-1,3-DIAMINO-2-PROPANOL 95.00% | 144912-84-5 | 5MG | $497.19 | 2021-12-16 | Buy |
| AK Scientific | 2354AQ | tert-butyl(3-amino-2-hydroxypropyl)carbamate | 144912-84-5 | 1g | $702.8 | 2021-12-16 | Buy |
| Ambeed | A679901 | tert-Butyl(3-amino-2-hydroxypropyl)carbamate 95% | 144912-84-5 | 5g | $1080 | 2021-12-16 | Buy |
| ChemBridge Corporation | BB-4086959 | tert-butyl(3-amino-2-hydroxypropyl)carbamate 95% | 144912-84-5 | 10g | $1385 | 2021-12-16 | Buy |
| Chemenu | CM327672 | tert-butylN-(3-amino-2-hydroxypropyl)carbamate 95%+ | 144912-84-5 | 100g | $2187 | 2021-12-16 | Buy |
N-BOC-1,3-DIAMINO-2-PROPANOL Chemical Properties,Uses,Production
Synthesis
24424-99-5
616-29-5
144912-84-5
The general procedure for the synthesis of tert-butyl (3-amino-2-hydroxypropyl)carbamate from di-tert-butyl dicarbonate and 1,3-diamino-2-propanol was as follows: 0.9 g of 1,3-diamino-2-propanol was added to a reactor equipped with magnetic stirring, and dissolved with 5 mL of 1 M sodium hydroxide solution. Subsequently, 1.0 g of di-tert-butyl dicarbonate was dissolved in 5 mL of 1,4-dioxane and this solution was slowly added dropwise to the reactor. The reaction mixture was stirred at room temperature for 5 hours and then warmed up to 50-65 °C for decompression distillation to remove most of the solvent, and the remaining solvent was dried by a vacuum pump to give a white viscous solid. The crude product was purified by silica gel column chromatography with gradient elution using dichloromethane-methanol-triethylamine (300:30:1, v/v/v) as eluent to give 600 mg of tert-butyl (3-amino-2-hydroxypropyl)carbamate in 69% yield.
References
[1] Patent: CN106893342, 2017, A. Location in patent: Paragraph 0016; 0017
[2] Patent: CN105503920, 2016, A. Location in patent: Paragraph 0011; 0057; 0058
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 2, p. 236 - 246
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 46, p. 9389 - 9404
[5] Patent: WO2005/66172, 2005, A1. Location in patent: Page/Page column 62
N-BOC-1,3-DIAMINO-2-PROPANOL Preparation Products And Raw materials
Raw materials
Preparation Products
N-BOC-1,3-DIAMINO-2-PROPANOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Compound Net Biotechnology Inc. | +8615303909093 | sales@compound-net.com | China | 2914 | 58 |
| Shanghai Kaimo Pharmaceutical Co., Ltd. | 021-50521023 18019779209 | sales@kaimopharm.com | China | 227 | 58 |
| Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd | 037188900765 18037465274 | enyawanglei@sina.cn | China | 14049 | 58 |
| Shanghai Targsense Scientific Co., Ltd. | 18916626092 | sales@targsense.com | China | 22 | 58 |
| Beijing Ouhe Technology Co., Ltd | 010-82967028 13522913783 | 2355560935@qq.com | China | 11776 | 60 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1994 | 58 |
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