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4-Methylpyridin-2-amine

4-Methylpyridin-2-amine Structure
4-Methylpyridin-2-amine structure
CAS No.
695-34-1
Chemical Name:
4-Methylpyridin-2-amine
Synonyms
2-AMINO-4-METHYLPYRIDINE;2-AMINO-4-PICOLINE;Aminopicoline;Rifaximin EP Impurity A;w45;W 45;4M2AP;ra1226;RA 1226;NSC 1490
CBNumber:
CB9854129
Molecular Formula:
C6H8N2
Molecular Weight:
108.14
MDL Number:
MFCD00149166
MOL File:
695-34-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:21:47
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4-Methylpyridin-2-amine Properties

Melting point 96-99 °C (lit.)
Boiling point 230 °C (lit.)
Density 1.0275 (estimate)
vapor pressure 3.71Pa at 25℃
refractive index 1.5560 (estimate)
Flash point 118 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMF: freely soluble
form Flakes
pka pK1: 7.48(+1) (25°C)
color Slightly yellow to beige or brown
Water Solubility SOLUBLE
Sensitive Hygroscopic
Merck 14,466
BRN 107066
InChI 1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)
InChIKey ORLGLBZRQYOWNA-UHFFFAOYSA-N
SMILES Cc1ccnc(N)c1
LogP 0.56-1.08
CAS DataBase Reference 695-34-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 394N1Z644H
NIST Chemistry Reference 2-Pyridinamine, 4-methyl-(695-34-1)
EPA Substance Registry System 2-Pyridinamine, 4-methyl- (695-34-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H301+H311+H331-H373
Precautionary statements  P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P314
PPE Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes  T
Risk Statements  45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25
Safety Statements  53-45-60-61-37/39-28A-26-36/37/39
RIDADR  UN 3086 6.1/PG 1
WGK Germany  3
RTECS  TJ5150000
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B
Toxicity LD50 oral in rat: 200mg/kg
REACH Registrations Active
Limited Quantities 100ml (liquid) or 0.5 Kg (solid)
Excepted Quantities Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 1

4-Methylpyridin-2-amine price More Price(82)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 123080 2-Amino-4-methylpyridine 99% 695-34-1 100g $65.7 2026-04-30 Buy
TCI Chemical A0402 2-Amino-4-methylpyridine >98.0%(GC)(T) 695-34-1 25g $55 2026-04-30 Buy
TCI Chemical A0402 2-Amino-4-methylpyridine >98.0%(GC)(T) 695-34-1 500g $332 2026-04-30 Buy
Usbiological 260400 2-Amino-4-picoline Asreported 695-34-1 100g $368 2026-06-03 Buy
Usbiological 260400 2-Amino-4-picoline Asreported 695-34-1 250g $552 2026-06-03 Buy
Product number Packaging Price Buy
123080 100g $65.7 Buy
A0402 25g $55 Buy
A0402 500g $332 Buy
260400 100g $368 Buy
260400 250g $552 Buy

4-Methylpyridin-2-amine Chemical Properties, Uses, Production

Chemical Properties

Light yellow to brown flakes

Uses

Intermediate, medicine.

Uses

4-Methylpyridin-2-amine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

General Description

4-Methylpyridin-2-amine acts as ligand and forms methoxo-bridged copper(II) complexes.

Biochem/physiol Actions

4-Methylpyridin-2-amine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.

Synthesis

A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.

Purification Methods

Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]

References

[1] Patent: CN107011254, 2017, A. Location in patent: Paragraph 0022; 0042; 0043; 0046; 0047

4-Methylpyridin-2-amine Preparation Products And Raw materials

Raw materials

2-Amino-3-chloro-4-picoline

Preparation Products

2-Amino-3,5-dichloro-4-methylpyridine 2-Amino-5-nitro-4-picoline 2-Bromo-3-iodo-isonicotinic acid 2-Amino-5-bromo-4-methylpyridine 2-Acetamido-5-bromoisonicotinic acid
2-Amino-isonicotinic acid hydrazide 2-(2,2-Dimethyl-propionylamino)-isonicotinic acid 4-Pyridinecarbonyl chloride, 2-fluoro- (9CI) 2-Amino-5-fluoro-4-picoline 2-Acetylamino-4-methylpyridine
2-Aminoisonicotinic acid Ethyl 2-Aminoisonicotinate 2-Acetamido-5-nitro-4-picoline 2-Hydroxy-4-pyridinecarboxaldehyde (2-Amino-pyridin-4-yl)-methanol
2-Fluoroisonicotinic acid 2-Acetamido-4-methyl-5-bromopyridine 2-Chloro-3-hydroxyisonicotinic acid 2-Bromo-4-methylpyridine 2-Nitropyridine-4-carboxylic acid
2-Acetamido-5-amino-4-picoline

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4-Methylpyridin-2-amine Suppliers

Global Suppliers ( 684)
Supplier Tel Email Country ProdList Advantage
Jinan Dexinjia Bio&Tech Co., Ltd 0531-82375818 15064153060 1329217348@qq.com China 1448 58
Jubilant Life Sciences(Shanghai)Ltd. 021-63907388-21 18017369769 jerry_zhang@jubl.com China 193 58
Shanghai Taijilin Industrial Co., Ltd. 02150630626 17717886015 kate@tajilin.com China 1342 58
Jiangxi Bairui Technology Co., Ltd 13026208279 13026208279 bwinchem@163.com China 186 58
Nanjing Hengbei Chemicals Co., Ltd. 025-58393656 18913958656 sales@hengbeichem.cn China 236 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Jinan Dexinjia Bio&Tech Co., Ltd 58
Jubilant Life Sciences(Shanghai)Ltd. 58
Shanghai Taijilin Industrial Co., Ltd. 58
Jiangxi Bairui Technology Co., Ltd 58
Nanjing Hengbei Chemicals Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81

Related articles

View Latest Price from 4-Methylpyridin-2-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Methylpyridin-2-amine pictures 2026-10-14 4-Methylpyridin-2-amine
695-34-1
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2-Amino-4-Methyl-Pyridin pictures 2026-05-28 2-Amino-4-Methyl-Pyridin
695-34-1
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
4-Methylpyridin-2-amine pictures 2026-03-20 4-Methylpyridin-2-amine
695-34-1
 $1.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

4-Methylpyridin-2-amine Spectrum

4-Methylpyridin-2-amine(695-34-1)MS4-Methylpyridin-2-amine(695-34-1)1HNMR4-Methylpyridin-2-amine(695-34-1)13CNMR4-Methylpyridin-2-amine(695-34-1)IR14-Methylpyridin-2-amine(695-34-1)IR24-Methylpyridin-2-amine(695-34-1)IR34-Methylpyridin-2-amine(695-34-1)Raman

695-34-1 (4-Methylpyridin-2-amine) Related Search:

5-Amino-2-chloro-3-picoline 2-Amino-3-ethyl-6-methylpyridine 2-METHYLPYRIDIN-3-AMINE,3-AMINO-2-METHYLPYRIDINE (3-AMINO-2-PICOLINE),3-Amino-2-methylpyridine ,97% 4-AMINO-2-METHYLPYRIDINE (4-AMINO-2-PICOLINE),2-METHYLPYRIDIN-4-AMINE,4-Amino-2-methylpyridine ,97% 5-Amino-3-methylpyridine
2,3-Diamino-5-methylpyridine 2-Amino-5-nitro-4-picoline 2-Amino-5-bromo-4-methyl-3-nitropyridine 2-Amino-3-nitro-4-picoline 2-Amino-4-(trifluoromethyl)pyridine
2-Amino-4,6-dimethylpyridine 4-Methylpyridin-2-amine 3-Amino-2-methoxy-6-picoline 5-Iodo-6-methyl-pyridin-2-ylamine 6-Amino-5-methylnicotinonitrile
6-Methyl-4-(trifluoromethyl)pyrid-2-yl hydrazine 2,6-Dichloro-4-methylpyridin-3-amine 5-Methylpyridin-3-amine

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99.995% trace Metals basis w45raschig 4-METHYL-2-PYRIDYLAMINE 4-METHYLPYRIDIN-2-AMINE 4-METHYL-PYRIDIN-2-YLAMINE AKOS BBS-00004343 AKOS 91145 TIMTEC-BB SBB004354 OTAVA-BB BB7015122364 SODIUM DICHROMATE 2H2O SODIUM DICHROMATE-2-HYDRATE SODIUM DICHROMATE, HYDROUS SODIUM BICHROMATE DIHYDRATE AURORA 11319 2-Amino-4-Methylpyridine,Nevirapine 2-Pyridinamine,4-methyl-(9CI) 2-AMINO-4-METHYL PYRODINE 2-AMINO-4-METHYL PYRIDINE 4-METHYLPYRIDIN-2-YLAMINE 2-Amino-4-methylpyridine, 98+% NSC 1490 NSC 176165 NSC 6972 2-AMINO-4-METHYLPYRIDINE FOR SYNTHESIS 2-Amino-4-methylpyridine ,99% 2-Amino-4-picoline,98% 2-AMino-4-picoline, 98% 100GR 2-Amino-4-picoline, 4-Methylpyridin-2-amine 4M2AP 4-Methyl-2-aminopyridine 4-Methyl-2-pyridamine 4-methyl-2-pyridinamin 4-Methyl-2-pyridinamine 4-Picoline, 2-amino- alpha-Amino-gamma-picoline Ascensil component of Ascensil component of Askensil Methyl-4 amino-2-pyridine methyl-4amino-2-pyridine Pyridine, 2-amino-4-methyl- RA 1226 ra1226 VMI 20-4 W 45 W 45 Raschig 2-amino-4-methyl-pyridin 2-amino-4-picolin 2-Amino-gamma-picoline 2-Aminop-4-picoline 2-Pyridinamine,4-methyl- w45 Rifaximin impurities Rifaximin Impurity 1 (Rifaximin EP Impurity A) 2-Amino-4-methylpyridine > 4-methylpyridine-2-amine 4-Methylpyridin-2-amine ISO 9001：2015 REACH 695-34-1 4-Methylpyridin-2-amine 2-Amio-4-Methylpyridine