| Identification | More | [Name]
4-Methylpyridin-2-amine | [CAS]
695-34-1 | [Synonyms]
2-AMINO-4-METHYLPYRIDINE
2-AMINO-4-PICOLINE
4-METHYL-2-PYRIDYLAMINE
4-METHYLPYRIDIN-2-AMINE
4-METHYL-PYRIDIN-2-YLAMINE
AKOS 91145
AKOS BBS-00004343
AURORA 11319
OTAVA-BB BB7015122364
SODIUM BICHROMATE
SODIUM BICHROMATE DIHYDRATE
SODIUM DICHROMATE
SODIUM DICHROMATE 2H2O
SODIUM DICHROMATE-2-HYDRATE
SODIUM DICHROMATE DIHYDRATE
SODIUM DICHROMATE, HYDROUS
TIMTEC-BB SBB004354
2-amino-4-methyl-pyridin
2-amino-4-picolin
2-Amino-gamma-picoline | [EINECS(EC#)]
234-190-3 | [Molecular Formula]
Cr2H4Na2O9 | [MDL Number]
MFCD00149166 | [Molecular Weight]
298 | [MOL File]
695-34-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow to brown flakes | [Melting point ]
96-99 °C (lit.) | [Boiling point ]
230 °C (lit.) | [density ]
1.0275 (estimate) | [vapor pressure ]
3.71Pa at 25℃ | [refractive index ]
1.5560 (estimate) | [Fp ]
118 °C
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMF: freely soluble | [form ]
Flakes | [pka]
pK1: 7.48(+1) (25°C) | [color ]
Slightly yellow to beige or brown | [Water Solubility ]
SOLUBLE | [Sensitive ]
Hygroscopic | [Detection Methods]
HPLC,GC,NMR | [Merck ]
14,466 | [BRN ]
107066 | [InChI]
1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8) | [InChIKey]
ORLGLBZRQYOWNA-UHFFFAOYSA-N | [SMILES]
Cc1ccnc(N)c1 | [LogP]
0.56-1.08 | [CAS DataBase Reference]
695-34-1(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Pyridinamine, 4-methyl-(695-34-1) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
695-34-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS06,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H301+H311+H331-H373 | [Precautionary statements ]
P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P314 | [Hazard Codes ]
T | [Risk Statements ]
R45:May cause cancer.
R60:May impair fertility.
R61:May cause harm to the unborn child.
R8:Contact with combustible material may cause fire.
R21:Harmful in contact with skin.
R25:Toxic if swallowed.
R26:Very Toxic by inhalation.
R34:Causes burns.
R42/43:May cause sensitization by inhalation and skin contact .
R48/23:Toxic: danger of serious damage to health by prolonged exposure through inhalation .
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin .
R33:Danger of cumulative effects.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 3086 6.1/PG 1
| [WGK Germany ]
3
| [RTECS ]
TJ5150000
| [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29333999 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B | [Toxicity]
LD50 oral in rat: 200mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow to brown flakes | [Uses]
Intermediate, medicine. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y | [General Description]
2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes. | [Biochem/physiol Actions]
2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro. | [Synthesis]
A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.
| [Purification Methods]
Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.] | [References]
[1] Patent: CN107011254, 2017, A. Location in patent: Paragraph 0022; 0042; 0043; 0046; 0047 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|