Estradiol valerate
- CAS No.
- 979-32-8
- Chemical Name:
- Estradiol valerate
- Synonyms
- delestrogen;β-Estradiol 17-valerate;Nuvelle;femogex;pharlon;estraval;Climaval;Valergen;deladiol;atladiol
- CBNumber:
- CB0300193
- Molecular Formula:
- C23H32O3
- Molecular Weight:
- 356.51
- MOL File:
- 979-32-8.mol
- Modify Date:
- 2024/5/6 14:49:57
| Melting point | 144°C |
|---|---|
| Boiling point | 438.83°C (rough estimate) |
| Density | 1.1024 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Practically insoluble in water, soluble in alcohol. |
| pka | 10.25±0.60(Predicted) |
| Merck | 13,3738 |
| BRN | 2480357 |
| InChI | InChI=1/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/s3 |
| InChIKey | RSEPBGGWRJCQGY-RBRWEJTLSA-N |
| SMILES | C[C@]12CC[C@]3([H])C4C=CC(O)=CC=4CC[C@@]3([H])[C@]1([H])CC[C@@H]2OC(=O)CCCC |&1:1,4,15,17,21,r| |
| CAS DataBase Reference | 979-32-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351-H361fd-H362-H410 | |||||||||
| Precautionary statements | P202-P260-P263-P264-P273-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 60-61 | |||||||||
| Safety Statements | 53-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KG5793000 | |||||||||
| HS Code | 29372390 | |||||||||
| NFPA 704 |
|
Estradiol valerate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2857 | Estradiol Valerate certified reference material, pharmaceutical secondary standard | 979-32-8 | 200MG | ₹22342.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E1631 | β-Estradiol 17-valerate ≥98% | 979-32-8 | 1G | ₹18954.58 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E0876 | β-Estradiol 17-Valerate min. 98.0 % | 979-32-8 | 1G | ₹6900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | E0876 | β-Estradiol 17-Valerate min. 98.0 % | 979-32-8 | 5G | ₹16000 | 2022-05-26 | Buy |
Estradiol valerate Chemical Properties,Uses,Production
Description
Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication. In women, it is used in hormone therapy for menopausal symptoms and low estrogen levels, hormone therapy for transgender women, and in hormonal birth control. It is also used in the treatment of prostate cancer in men. The medication is taken by mouth or by injection into muscle or fat once every 1 to 4 weeks.
Chemical Properties
White to off-white crystalline powder, odorless. Insoluble in water, easily soluble in ethanol, acetone, chloroform, slightly soluble in vegetable oil.
Uses
Estradiol valerate is a female hormone (estrogen). It is used to reduce symptoms of menopause which are vaginal dryness, hot flashes, and others. The symptoms of menopause manifest because the body is making less estrogen; with estradiol valerate, these symptoms are brought to the lowest minimum. This medication therapy can also produce enough estrogen in women with ovarian failure, hypogonadism and can be used by men to treat prostate cancer (palliation only).
Indications
Estradiol valerate is commercially available as an intramuscular injection as the product Delestrogen and is indicated for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). Estradiol valerate is also available in combination with Dienogest as the commercially available product Natazia used for the prevention of pregnancy and for the treatment of heavy menstrual bleeding.
Definition
ChEBI: Estradiol valerate is a steroid ester. It is the parenterally-administered synthetic valerate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
General Description
Estradiol valerate is a synthetic hormone that is extensively metabolized to estradiol and valeric acid before reaching the systemic circulation. It is well suited for treatment of the characteristic symptoms accompanying menopause in women.
Side effects
As with all pharmaceutical medicines, some unwanted effects can occur from the use of estradiol valerate tablets.
Always consult a physician for medical advice before use.
Common side effects may include: bloating, vomiting, nausea, breast tenderness, headache, weight changes, and mood changes.
More severe side effects may include mental changes, breast lumps, vaginal bleeding, liver damage, increased thirst, and sudden vision loss.
Safety Profile
Suspected carcinogen with carcinogenic and teratogenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.
Estradiol valerate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Asg Biochem Pvt. Ltd | +91-9650436669 +91-9650436669 | New Delhi, India | 25 | 58 | Inquiry |
| Shakti Life Science | +91-9930420063 +91-9930420063 | Maharashtra, India | 28 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Symbiotec Pharma Lab Pvt Ltd | +91-7316676406 +91-7316676405 | Madhya Pradesh, India | 71 | 58 | Inquiry |
| Vincit Labs Pvt Ltd | +91-1127357490 +91-1127357490 | New Delhi, India | 15 | 58 | Inquiry |
| Di Bombay Pharma | 08047627138 | Nagpur, India | 8 | 58 | Inquiry |
| Vishal Health Specialities | 08048250468Ext 351 | Nagpur, India | 9 | 58 | Inquiry |
| Sanjivani Pharma | 08048371780Ext 182 | Gujarat, India | 8 | 58 | Inquiry |
| Swati Spentose Pvt. Ltd. | +91 22 66332427 | New Delhi, India | 17 | 58 | Inquiry |
| Selvok Pharmaceutical Co | 08048372605Ext 180 | Gujarat, India | 3 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Asg Biochem Pvt. Ltd | 58 |
| Shakti Life Science | 58 |
| Ralington Pharma | 58 |
| Symbiotec Pharma Lab Pvt Ltd | 58 |
| Vincit Labs Pvt Ltd | 58 |
| Di Bombay Pharma | 58 |
| Vishal Health Specialities | 58 |
| Sanjivani Pharma | 58 |
| Swati Spentose Pvt. Ltd. | 58 |
| Selvok Pharmaceutical Co | 58 |
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