Cyproterone acetate
- CAS No.
- 427-51-0
- Chemical Name:
- Cyproterone acetate
- Synonyms
- ANDROCUR;CYPROSTAT;CIPROTERONE ACETATE;SH-714;nsc-81430;Cyproviron;cyprosteroneacetate;CYPROTERONE ACETATE;CYPROFERONE ACETATE;cyproteron-racetate
- CBNumber:
- CB7338955
- Molecular Formula:
- C24H29ClO4
- Molecular Weight:
- 416.94
- MOL File:
- 427-51-0.mol
- Modify Date:
- 2024/4/29 14:28:21
| Melting point | 200-201°C |
|---|---|
| Boiling point | 528.8°C (rough estimate) |
| Density | 1.0677 (rough estimate) |
| refractive index | 1.4429 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Practically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol. |
| color | White to Off-White |
| λmax | 281nm(MeOH)(lit.) |
| Merck | 14,2774 |
| InChIKey | UWFYSQMTEOIJJG-KIXORDEXNA-N |
| SMILES | C[C@@]12C(=CC(=O)[C@@H]3C[C@H]13)C(Cl)=C[C@@]1([H])[C@]3([H])CC[C@@](C(=O)C)(OC(=O)C)[C@@]3(C)CC[C@]21[H] |&1:1,6,8,12,14,18,26,30,r| |
| EPA Substance Registry System | 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)- (427-51-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312+H332-H351 | |||||||||
| Precautionary statements | P202-P261-P280-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-40-36/37/38 | |||||||||
| Safety Statements | 22-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GZ2230000 | |||||||||
| HS Code | 29372900 | |||||||||
| NFPA 704 |
|
Cyproterone acetate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2809 | Cyproterone acetate Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material | 427-51-0 | 50MG | ₹30970.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C3412 | Cyproterone acetate ≥98% | 427-51-0 | 250MG | ₹21303.6 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2942 | Cyproterone Acetate | 427-51-0 | 200MG | ₹9600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C2942 | Cyproterone Acetate | 427-51-0 | 1G | ₹12300 | 2022-05-26 | Buy |
Cyproterone acetate Chemical Properties,Uses,Production
Description
Cyproterone acetate (CPA) is an androgen receptor antagonist. It binds to human androgen receptors (Ki = 14 nM) and inhibits dihydrotestosterone-induced androgen receptor activation in CV-1 cells (IC50 = 26 nM). CPA (30 mg/kg) decreases ventral prostate weight in castrated immature rats. It also suppresses accessory sexual glands and fertility in adult male rats when administered at a dose of 10 mg/kg. CPA (0.3 μM) also induces apoptosis in primary adult female rat hepatocytes. Formulations containing cyproterone acetate have been used in the treatment of androgenization in females.
Chemical Properties
Crystalline Solid
Uses
Cyproterone acetate (CPA) has been shown to exert gestagenic and glucocorticoid effects. Because it inhibits the negative diencephalic pituitary testicular feedback system, it lowers luteinizing hormone (LH) and testosterone production and plasma levels. cyproterone acetate is both an anti-androgen and a progestogen. CPA is used in combined birth control pills, in the treatment of androgen-dependent skin and hair conditions such as acne (Combined with estrogen), seborrhea, excessive hair growth, and scalp hair loss, high androgen levels, in transgender hormone therapy, to treat prostate cancer, to reduce sex drive in sex offenders or men with paraphilias or hypersexuality, to treat early puberty, and for other uses. It is used both at low doses and at higher doses.
Indications
Cyproterone acetate is a progestational antiandrogen that blocks androgen receptor binding and suppresses androgen-sensitive tissues. It is available in a topical form in Europe for the treatment of hirsutism.
Mechanism of action
The mechanism of action of Cyproterone acetate at the molecular level has never been described conclusively. Studies have found that in rat ventral prostate nuclei, CPA interferes with androgen binding to the androgen receptor. It is possible that CPA interferes with the translocation of the androgen receptor from the cytoplasm to the nuclear compartment. At the transcription level, the effects of CPA also include a reduction of androgen-dependent cellular functions, such as a reduction of acid phosphatase, prostate-specific androgen, and androgen-dependent enzymes such as 5-a-reductase[1].
Side effects
Vbreast tenderness and swelling. Tiredness and weakness (fatigue). Depression or mood changes. Hot flushes or sweats. Swelling in parts of the body (fluid build up). Weight changes. Liver changes (you will have regular blood tests to check for this). Shortness of breath.
References
[1] Schr?der F, et al. Cyproterone Acetate-Mechanism of Action and Clinical Effectiveness in Prostate Cancer Treatment. Cancer, 1993; 72: 3810-3815.
Cyproterone acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Swati Spentose Pvt Ltd | +91-2261505232 +91-2261505232 | Maharashtra, India | 44 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| CIPLA LIMITED | +91 22 24826000 | New Delhi, India | 72 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Samchem India Private Limited | 08048618089 | Delhi, India | 5 | 58 | Inquiry |
| Shaivya Pharmachem. | 08048371708Ext 729 | Gujarat, India | 56 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| PANCHSHEEL ORGANICS LTD | 58 |
| Cipla Ltd | 58 |
| Swati Spentose Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| BDR Pharmaceuticals International Pvt Ltd | 58 |
| CIPLA LIMITED | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Samchem India Private Limited | 58 |
| Shaivya Pharmachem. | 58 |
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