| Identification | Back Directory | [Name]
Cyproterone acetate | [CAS]
427-51-0 | [Synonyms]
SH-714
ANDROCUR
CYPROSTAT
nsc-81430
Cyproviron
Androcurone acetate
cyproteron-racetate
cyprosteroneacetate
CYPROTERONE ACETATE
CYPROFERONE ACETATE
CIPROTERONE ACETATE
Androcur, Cyprostat
CyproteroneAcetateEdmf
CyproteroneAcetateedmfep5
cyproterone17-alpha-acetate
* Color Pronk (cyproterone)
Cyproterone acetate(Androcur)
Cyproterone Acetate BP2000,EP2000
Cyproterone acetate for peak identification
6-Chloro-1α,2α-methylene-3,20-dioxopregna-4,6-dien-17-yl acetate
20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3
6)-pregnadiene-17-alpha-ol-3,20-dione17-2-alpha-methylene-6-chloro-(sup4
6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
1,2-alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione17-alpha-acetate
6-chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesteroneacetate
6-chloro-delta(sup6)-1,2-alpha-methylene-17-alpha-hydroxyprogesteroneacetat
1,2-alpha-methylene-6-chloro-delta(sup6)-17-alpha-hydroxyprogesteroneacetat
6-chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup6)-progesteroneaceta
4,6-PREGNADIEN-6-CHLORO-1-ALPHA, 2-ALPHA-METHYLENE-17-OL-3,20-DIONE ACETATE
1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio
17-alpha-acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dio
6-chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dioneacet
6-Chloro-1β,2β-dihydro-17-hydroxy-3μH-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate
(1β,2β)-17-(acetyloxy)-6-chloro-1,2-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
6-chloro-1b,2b-dihydro-17-hydroxy-3'h-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
6-CHLORO-1BETA,2BETA-DIHYDRO-17-HYDROXY-3'H-CYCLOPROPA[1,2]-PREGNA-1,4,6-TRIENE-3,20-DIONE ACETATE
6-chloro-1-beta,2-beta-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
3H-Cyclopropa1,2pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)- | [EINECS(EC#)]
207-048-3 | [Molecular Formula]
C24H29ClO4 | [MDL Number]
MFCD00864671 | [MOL File]
427-51-0.mol | [Molecular Weight]
416.94 |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
200-201°C | [Boiling point ]
528.8°C (rough estimate) | [density ]
1.0677 (rough estimate) | [refractive index ]
1.4429 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Practically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol. | [form ]
neat | [color ]
White to Off-White | [λmax]
281nm(MeOH)(lit.) | [Merck ]
14,2774 | [InChIKey]
UWFYSQMTEOIJJG-KIXORDEXNA-N | [SMILES]
C[C@@]12C(=CC(=O)[C@@H]3C[C@H]13)C(Cl)=C[C@@]1([H])[C@]3([H])CC[C@@](C(=O)C)(OC(=O)C)[C@@]3(C)CC[C@]21[H] |&1:1,6,8,12,14,18,26,30,r| | [EPA Substance Registry System]
3'H-Cyclopropa[ 1,2]pregna-1,4,6-triene-3, 20-dione, 17-(acetyloxy)-6-chloro-1, 2-dihydro-, (1.beta.,2.beta.)-(427-51-0) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
antiparasitic, fasciolicide | [Uses]
The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne. | [Uses]
Used as an antiandrogen. Combinded with estrogen in the treatment of acne | [Description]
Cyproterone acetate (CPA) is an androgen receptor antagonist.1 It binds to human androgen receptors (Ki = 14 nM) and inhibits dihydrotestosterone-induced androgen receptor activation in CV-1 cells (IC50 = 26 nM). CPA (30 mg/kg) decreases ventral prostate weight in castrated immature rats. It also suppresses accessory sexual glands and fertility in adult male rats when administered at a dose of 10 mg/kg.2 CPA (0.3 μM) also induces apoptosis in primary adult female rat hepatocytes.3 Formulations containing cyproterone acetate have been used in the treatment of androgenization in females. | [Originator]
Androcur ,Schering,W. Germany,1973 | [Definition]
ChEBI: Cyproterone acetate is a steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas. It has a role as an androgen antagonist, a progestin and a geroprotector. It is a 20-oxo steroid, a 3-oxo-Delta(4) steroid, a chlorinated steroid, a steroid ester and an acetate ester. It is functionally related to a cyproterone. | [Indications]
Cyproterone acetate is a progestational antiandrogen
that blocks androgen receptor binding and suppresses
androgen-sensitive tissues. It is available in a
topical form in Europe for the treatment of hirsutism. | [Manufacturing Process]
2.34 g of 1,2α-methylene-δ4,6-pregnadiene-17α-ol-3,20-dione-17-acetate are
dissolved in 18.25 cc of ethylene chloride which contains 844 rng of
perbenzoic acid. The solution is stored for 16 hours at +5°C and 7 hours at
room temperature. It is then diluted with methylene chloride and, with
aqueous ferrous sulfate solution, sodium bicarbonate solution and with water
washed until neutral.
The organic phase is dried over sodium sulfate and then concentrated to
dryness. 1.62 g of the thus obtained crude 1,2α-methylene-6,7α-oxido-δ4-
pregnene-17α-ol-3,20-dione-17-acetate are dissolved in 109 cc of glacial
acetic acid. This solution is then saturated at room temperature with hydrogen
chloride gas and stored for 20 hours, It is then diluted with methylene
chloride and washed with water until neutral.
The organic phase is dried over sodium sulfate and then concentrated to
dryness. The thus obtained crude 6-chloro-1α-chloromethyl-δ4,6-pregnadiene17α-ol-3,20-dione-17-acetate is heated to boiling in 20 cc of collidine for 20
minutes under nitrogen. After dilution with ether it is washed with 4 N
hydrochloric acid and washed with water until neutral.
After drying over sodium sulfate and concentration to vacuum the remaining
residue is subjected to chromatography over silica gel. Using a benzene-ethyl
acetate mixture (19:1) there is eluated 900 mg of 6-chloro-1,2α-methyleneδ4,6-pregnadiene-17α-ol-3,20-dione-17-acetate, which upon recrystallization
from isopropyl ether melts at 200° to 201°C. | [Therapeutic Function]
Antiandrogen | [Mechanism of action]
The mechanism of action of Cyproterone acetate at the molecular level has never been described conclusively. Studies have found that in rat ventral prostate nuclei, CPA interferes with androgen binding to the androgen receptor. It is possible that CPA interferes with the translocation of the androgen receptor from the cytoplasm to the nuclear compartment. At the transcription level, the effects of CPA also include a reduction of androgen-dependent cellular functions, such as a reduction of acid phosphatase, prostate-specific androgen, and androgen-dependent enzymes such as 5-a-reductase[1]. | [Clinical Use]
#N/A | [Side effects]
Vbreast tenderness and swelling. Tiredness and weakness (fatigue). Depression or mood changes. Hot flushes or sweats. Swelling in parts of the body (fluid build up). Weight changes. Liver changes (you will have regular blood tests to check for this). Shortness of breath.
| [Drug interactions]
Potentially hazardous interactions with other drugs
None known | [Metabolism]
Cyproterone is metabolised by various pathways including
hydroxylation and conjugation; about 35% of a dose is
excreted in urine, the remainder being excreted in the bile.
The principal metabolite, 15β-hydroxycyproterone, has
anti-androgenic activity | [References]
[1] Schr?der F, et al. Cyproterone Acetate-Mechanism of Action and Clinical Effectiveness in Prostate Cancer Treatment. Cancer, 1993; 72: 3810-3815. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
20/21/22-40-36/37/38 | [Safety Statements ]
22-36-26 | [WGK Germany ]
3
| [RTECS ]
GZ2230000
| [HS Code ]
29372900 | [Hazardous Substances Data]
427-51-0(Hazardous Substances Data) | [Uses]
Corroles are a class of tetradentate nitrogen ligands analogous to porphyrins. The corroles can act as trianionic ligands toward metal ions, and in particular, stabilize metal ions in high oxidation states such as Fe(IV), Co(IV) and Co(V).
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