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ジフェノキシン

ジフェノキシン 化学構造式
28782-42-5
CAS番号.
28782-42-5
化学名:
ジフェノキシン
别名:
1-(3-シアノ-3,3-ジフェニルプロピル)-4-フェニル-4-ピペリジンカルボン酸;ジフェノキシン
英語化学名:
Difenoxinum
英語别名:
Difenoxine;Difenoxinum;McN-JR-15403-11;Difenoxilic Acid;Difenoxylic Acid;Diphenoxylic Acid;Diphenoxylate Impurity A;UFIVBRCCIRTJTN-UHFFFAOYSA-N;Diphenoxylate EP impurity A;1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic Acid
CBNumber:
CB01178506
化学式:
C28H28N2O2
分子量:
0
MOL File:
28782-42-5.mol

ジフェノキシン 物理性質

沸点 :
632.7±55.0 °C(Predicted)
比重(密度) :
1.175±0.06 g/cm3(Predicted)
酸解離定数(Pka):
3.55±0.20(Predicted)

安全性情報

HSコード  2933330000

ジフェノキシン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ジフェノキシン 化学特性,用途語,生産方法

効能

止瀉薬, 蠕動抑制薬, オピオイド受容体作動薬

Originator

Lyspafena,Cilag Chemie,W. Germany,1980

使用

The active metabolite of Diphenoxylate. Antiperistaltic; antidiarrheal. This is a controlled substance (opiate).

定義

ChEBI: A piperidinemonocarboxylic acid that is 4-phenylpiperidine-4-carboxylic acid in which the hydrogen attached to the nitrogen atom is substituted by a 3-cyano-3,3-diphenylpropyl group.

Manufacturing Process

To a stirred solution of 5.52 parts of t-potassiurn butanolate in 60 parts of dimethylsulfoxide are added 1.7 parts of ethyl-1-(3-cyano-3,3- diphenylpropyl)-4-phenylisonipecotate hydrochloride and the whole is stirred on an oil bath (90°C) for 4 hours. The reaction mixture is cooled (30°C) and poured onto 180 parts of water with stirring. After two extractions with benzene, the aqueous phase is acidified with glacial acetic acid to pH 6.5 with stirring. The precipitated product is filtered off, washed with water, dried, dissolved in 50 parts of 0.4 N potassium hydroxide and precipitated again with glacial acetic acid. The crude free base is filtered off and dissolved in a mixture of 2-propanol and chloroform and gaseous hydrogen chloride is introduced into the solution. The whole is filtered and the filtrate is evaporated. The residue is mixed with benzene and the latter is evaporated again. The residue is recrystallized from 2-propanol, yielding 1-(3-cyano-3,3- diphenylpropyl)-4-phenylisonipecotic acid hydrochloride.

brand name

Dioctin;Lyspafen;Lyspofenac;Motofen.

Therapeutic Function

Antiperistaltic

世界保健機関(WHO)

Difenoxin is the principal metabolite of diphenoxylate. See WHO comment for diphenoxylate.

ジフェノキシン 上流と下流の製品情報

原材料

準備製品


ジフェノキシン 生産企業

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28782-42-5(ジフェノキシン)キーワード:


  • 28782-42-5
  • Difenoxinum
  • 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid
  • McN-JR-15403-11
  • 1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic Acid
  • Difenoxilic Acid
  • Difenoxine
  • Difenoxylic Acid
  • Diphenoxylic Acid
  • Diphenoxylate EP impurity A
  • UFIVBRCCIRTJTN-UHFFFAOYSA-N
  • 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid
  • Diphenoxylate Impurity A
  • 1-(3-シアノ-3,3-ジフェニルプロピル)-4-フェニル-4-ピペリジンカルボン酸
  • ジフェノキシン
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