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ビアペネム

ビアペネム 化学構造式
120410-24-4
CAS番号.
120410-24-4
化学名:
ビアペネム
别名:
6-[[(4R,5S,6S)-2-カルボキシラト-6β-[(R)-1-ヒドロキシエチル]-4α-メチル-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-3-イル]チオ]-6,7-ジヒドロ-5H-ピラゾロ[1,2-a][1,2,4]トリアゾール-4-イウム;6-[[(4R,5S,6S)-2-カルボキシラト-6β-[(1R)-1-ヒドロキシエチル]-4α-メチル-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-3-イル]チオ]-6,7-ジヒドロ-5H-ピラゾロ[1,2-a]-s-トリアゾール-4-イウム;6-[[(4R,5β)-2-カルボキシラト-4α-メチル-6β-[(R)-1-ヒドロキシエチル]-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-3-イル]チオ]-6,7-ジヒドロ-5H-ピラゾロ[1,2-a][1,2,4]トリアゾール-4-イウム;(4R,5S,6S)-3-(6,7-ジヒドロ-5H-ピラゾロ[1,2-a][1,2,4]トリアゾール-4-イウム-6-イルチオ)-6-[(1R)-1-ヒドロキシエチル]-4-メチル-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-2-カルボキシラート;ビアペネム;オメガシン;ビアペネム (JAN)
英語化学名:
Biapenem
英語别名:
L-627;BIAPENEM;OMegacin;LJC-10627;Biapenern;CL 186815;Crude Grade CL 186-815;BiapeneM USP
CBNumber:
CB0219286
化学式:
C15H18N4O4S
分子量:
350.39
MOL File:
120410-24-4.mol

ビアペネム 物理性質

融点 :
265-271°C (dec.)
比旋光度 :
D20 -32.9° (c = 0.5)
貯蔵温度 :
-20?C Freezer
溶解性:
H2O: ≥5mg/mL (warmed)
外見 :
powder
色:
white to beige
InChIKey:
MRMBZHPJVKCOMA-YJFSRANCSA-N
CAS データベース:
120410-24-4(CAS DataBase Reference)

安全性情報

WGK Germany  3

ビアペネム 価格 もっと(12)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01LKTB3203 ビアペネム
Biapenem
120410-24-4 10mg ¥12100 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01LKTB3203 ビアペネム
Biapenem
120410-24-4 25mg ¥20700 2018-12-26 購入
東京化成工業 B5522 ビアペネム >98.0%(GC)
Biapenem >98.0%(GC)
120410-24-4 100mg ¥26600 2018-12-04 購入
東京化成工業 B5522 ビアペネム >98.0%(GC)
Biapenem >98.0%(GC)
120410-24-4 25mg ¥9400 2018-12-04 購入
Sigma-Aldrich Japan SML0306 ≥98% (HPLC)
Biapenem ≥98% (HPLC)
120410-24-4 50mg ¥58200 2018-12-25 購入

ビアペネム 化学特性,用途語,生産方法

効能

抗生物質, 細胞壁合成阻害薬

商品名

オメガシン (Meiji Seikaファルマ); オメガシン (Meiji Seikaファルマ)

説明

Biapenem was introduced in Japan as a parenteral treatment for bacterial infections. This new 1-β-methylcarbapenem can be prepared by reaction of commercially available 4-nitrobenzyl protected β-methylcarbapenem enolphosphate with mercapto bicyclotriazolium chloride, obtained in 11 steps starting from hydrazine, followed by deprotection of the carboxylic acid function. Biapenem is a bacterial cell wall synthesis inhibitor with a broad spectrum in vitro antibacterial activity encompassing many Gramnegative and Gram-positive aerobic and anaerobic bacteria, including species producing β-lactamases. Like imipenem, biapenem is moderately active against fnferococcus faecalis and E. faecuirn and is inactive against methicillin-resistant Staphylococcus aureus. Biapenem is stable to hydrolysis by human renal dihydropeptidase I (DHP-I) and therefore does not require the coadministration of a DHP-I inhibitor. In clinical trials, biapenem showed good clinical and microbiological efficacy in the treatment of patients with intraabdominal, lower respiratory tract and complicated urinary tract infections. After intravenous administration, the drug is widely distributed, has linear pharmacokinetics and is mainly excreted in the urine with an elimination half-life of approximately 1 h. Biapenem is generally well tolerated, the most common adverse events being skin eruptions/rashes, nausea and diarrhea.

化学的特性

Off-White Solid

Originator

Wyeth (US)

使用

Biapenem is a carbapenem antibiotic. It has in vitro activity against anaerobes. Biapenem is a new parenteral carbapenem antibacterial agent with a broad spectrum of in vitro antibacterial activity encompassing many Gram-negative and Gram-positive aerobic

使用

An carbapenem antibacterial.

使用

A carbepenem with antibacterial action

brand name

Omegacin

抗菌性

A semisynthetic carbapenem with a 2-substituted triazolium moiety. It has broad-spectrum activity against most aerobic and anaerobic Gram-positive and Gram-negative organisms. It is equivalent to, or slightly more active than, imipenem against Gram-negative aerobic bacteria and slightly less active than imipenem against Gram-positive organisms. It is stable to hydrolysis by dehydropeptidase. It is not hydrolyzed by most serine β-lactamases, but like all carbapenems and penems is readily hydrolyzed by carbapenemases. It penetrates into bronchial epithelial lining fluid with peak concentrations of 2.4–4.4 mg/L. The plasma half-life is 1.5–1.9 h. The potential for neurotoxicity is less than that of imipenem.

臨床応用

Biapenem is a newer second-generation carbapenem withchemical and microbiological properties similar to those ofmeropenem. Thus, it has broad-spectrum antibacterial activitythat includes most aerobic Gram-negative and Grampositivebacteria and anaerobes. Biapenem is stable toDHP-I67 and resistant to most β-lactamases. It is claimedto be less susceptible to metallo-β-lactamases than eitherimipenem or meropenem. It is not active orally.

ビアペネム 上流と下流の製品情報

原材料

準備製品


ビアペネム 生産企業

Global( 227)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21954 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292893290
+8613292893290 Nancy@SpeedGainpharma.com CHINA 1020 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20331 58

120410-24-4(ビアペネム)キーワード:


  • 120410-24-4
  • 6-[[(4r,5s,6s)-2-carboxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt
  • BIAPENEM
  • (4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • 6-[[(4R,5S,6S)-2-Carboxylato-6β-[(1R)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a]-s-triazol-4-ium
  • 6-[[(4R,5S,6S)-2-Carboxylato-6β-[(R)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium
  • 6-[[(4R,5β)-2-Carboxylato-4α-methyl-6β-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium
  • L-627
  • LJC-10627
  • protected biapenum
  • protected biapenem
  • Biapenem ,98%
  • Crude 
  • Grade 
  • 6-{[(4R,5S,6S)-2-carboxylato-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl}-5H,6H,7H-2,4000000$l^{5},8000000-pyrazolo[1,2-a][1$l^{5},2,4]triazol-4-yliuM
  • 6-[[(4R,5S,6S)-2-Carboxylato-6β-[(1R)-1-hydroxyethyl]-4α-Methyl-7-oxo-1-azabicyclo[3.2.0]he
  • Biapenern
  • OMegacin
  • BiapeneM Crude
  • CL 186815
  • CL 186-815
  • BiapeneM USP
  • 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-, inner salt
  • Biapenem, >=99%
  • Biapenem CAS:120410-24-4
  • 6-[[(4R,5S,6S)-2-カルボキシラト-6β-[(R)-1-ヒドロキシエチル]-4α-メチル-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-3-イル]チオ]-6,7-ジヒドロ-5H-ピラゾロ[1,2-a][1,2,4]トリアゾール-4-イウム
  • 6-[[(4R,5S,6S)-2-カルボキシラト-6β-[(1R)-1-ヒドロキシエチル]-4α-メチル-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-3-イル]チオ]-6,7-ジヒドロ-5H-ピラゾロ[1,2-a]-s-トリアゾール-4-イウム
  • 6-[[(4R,5β)-2-カルボキシラト-4α-メチル-6β-[(R)-1-ヒドロキシエチル]-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-3-イル]チオ]-6,7-ジヒドロ-5H-ピラゾロ[1,2-a][1,2,4]トリアゾール-4-イウム
  • (4R,5S,6S)-3-(6,7-ジヒドロ-5H-ピラゾロ[1,2-a][1,2,4]トリアゾール-4-イウム-6-イルチオ)-6-[(1R)-1-ヒドロキシエチル]-4-メチル-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-2-カルボキシラート
  • ビアペネム
  • オメガシン
  • ビアペネム (JAN)
  • カルバペネム系抗生物質
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