PTC-209 (PTC209
|
|
|
- CAS番号.
- 315704-66-6
- 化学名:
- 别名:
- 英語名:
- PTC-209 (PTC209
- 英語别名:
- PTC-209;CS-1315;PTC 209 NEW;PTC-209, >=98%;PTC-209 (PTC209;PTC-209 free base;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine;N-(2,6-dibroMo-4-Methoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyriMidin-3-yl)thiazol-2-aMine;2-THIAZOLAMINE, N-(2,6-DIBROMO-4-METHOXYPHENYL)-4-(2-METHYLIMIDAZO[1,2-A]PYRIMIDIN-3-YL)-;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine PTC-209
- CBNumber:
- CB02682264
- 化学式:
- C17H13Br2N5OS
- 分子量:
- 495.19
- MOL File:
- 315704-66-6.mol
- MSDS File:
- SDS
|
PTC-209 (PTC209 物理性質
- 比重(密度) :
- 1.86±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：可溶20mg/mL、透明
- 酸解離定数(Pka):
- 3.77±0.30(Predicted)
- 外見 :
- 粉
- 色:
- 白から茶色
- 安定性：:
- -20°C の DMSO 溶液で最大 3 か月間保存できます。
- CAS データベース:
- 315704-66-6
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
T |
|
|
| Rフレーズ |
25 |
|
|
| Sフレーズ |
45 |
|
|
| RIDADR |
UN 2811 6.1 / PGIII |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
| P301+P310 |
飲み込んだ場合：直ちに医師に連絡すること。 |
|
PTC-209 (PTC209 価格
もっと(4)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC5191 |
PTC 209 |
315704-66-6 |
10mg |
￥83000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC5191 |
PTC 209 |
315704-66-6 |
50mg |
￥352000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1143 |
≥98% (HPLC)
PTC-209 ≥98% (HPLC) |
315704-66-6 |
5mg |
￥19900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1143 |
≥98% (HPLC)
PTC-209 ≥98% (HPLC) |
315704-66-6 |
25mg |
￥64100 |
2024-03-01 |
購入 |
PTC-209 (PTC209 化学特性,用途語,生産方法
使用
Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth. It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.[Cayman Chemical]
Biochem/physiol Actions
PTC-209 inhibits the expression of the oncogene BMI-1 (B lymphoma Mo-MLV insertion region 1 homolog), which encodes a polycomb group RING finger protein involved in cell cycle. PTC-209 lowers the self-renewal properties of colorectal cancer-initiating cells (CICs) The compound inhibits tumor growth, and reduces the levels of CICs present in colon cancer tumor xenografts in mice.
PTC-209 (PTC209 上流と下流の製品情報
原材料
準備製品
PTC-209 (PTC209 生産企業
Global( 100)Suppliers
315704-66-6()キーワード:
- 315704-66-6
- PTC-209 (PTC209
- PTC-209
- N-(2,6-dibroMo-4-Methoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyriMidin-3-yl)thiazol-2-aMine
- N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine
- N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine PTC-209
- PTC-209, >=98%
- 2-THIAZOLAMINE, N-(2,6-DIBROMO-4-METHOXYPHENYL)-4-(2-METHYLIMIDAZO[1,2-A]PYRIMIDIN-3-YL)-
- PTC-209 free base
- PTC 209 NEW
- CS-1315