CGP55845 化学特性,用途語,生産方法
使用
CGP is a potent, selectie GABAB receptor antagonist.
生物活性
Potent, selective GABA B receptor antagonist (IC 50 = 5 nM) that prevents agonist binding (pK i = 8.35) and inhibits GABA and glutamate release (pEC 50 values are 8.08 and 7.85 respectively). Inhibits GABA B responses to baclofen (IC 50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro .
Biochem/physiol Actions
CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.
CGP55845 上流と下流の製品情報
原材料
準備製品