6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル
6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル 物理性質
- 融点 :
- 180
- 沸点 :
- 390.5±52.0 °C(Predicted)
- 比重(密度) :
- 1.25±0.1 g/cm3(Predicted)
- 酸解離定数(Pka):
- 11.33±0.70(Predicted)
- InChIKey:
- QMFBVGUFEGVPNG-UHFFFAOYSA-N
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
Xi |
|
|
| 国連危険物分類 |
IRRITANT |
|
|
| HSコード |
2933599590 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
 |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P301+P310 |
飲み込んだ場合：直ちに医師に連絡すること。 |
|
6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル 価格
もっと(6)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC355893 |
ethyl 6-methyl-4-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
33458-26-3 |
1g |
￥255600 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC355893 |
ethyl 6-methyl-4-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
33458-26-3 |
5g |
￥864600 |
2018-12-26 |
購入 |
|
Sigma-Aldrich Japan
|
S170372 |
AldrichCPR
6-ME-4-PH-2-THIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER AldrichCPR |
33458-26-3 |
50MG |
￥24400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
S170372 |
AldrichCPR
6-ME-4-PH-2-THIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER AldrichCPR |
33458-26-3 |
1ea |
￥18700 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS061399 |
6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル
Ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
33458-26-3 |
500mg |
￥144900 |
2024-03-01 |
購入 |
6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル 化学特性,用途語,生産方法
使用
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process middle.
合成
In a 10-mL round-bottom flask equipped with a condenser, a mixture of the aromatic aldehyde (1 mmol), ethyl acetoacetate (1 mmol), urea or thiourea (1.5 mmol) and [Dsbim]Cl (0.0376 g, 10 mol%) was stirred at 80 °C, and the resulting mixture was kept under continuous stirring for lengths of time as specified in Table 3, with the progress of the reaction was followed by TLC. After completion of the reaction, the mixture was cooled to room temperature, and 3 mL of water was added. The ionic liquid was dissolved in water and filtered for separation of the crude product. The separated product was washed twice with water (2 9 3 mL). For recycling the catalysts, after the solid products were thoroughly washed with water, the water containing the ionic liquid (IL is soluble in water) was evaporated under reduced pressure, and the ionic liquid was recovered and reused. The solid product was purified by a recrystallization procedure in ethanol. All of the desired product(s) were characterized by comparison of their physical data with those of known compounds. Entry: 13 Product: 4m; Yield: 90% Mp: 208-210°C; Lit. Mp: 205-206 [23]°C
6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル 上流と下流の製品情報
原材料
準備製品
6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル 生産企業
Global( 41)Suppliers
33458-26-3(6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル)キーワード:
- 33458-26-3
- 5118-36-5
- 6-ME-4-PH-2-THIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- 4-methyl-6-phenyl-2-thioxo-3,6-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
- A0951/0044480
- ethyl 4-methyl-6-phenyl-2-sulfanylidene-3,6-dihydro-1H-pyrimidine-5-carboxylate
- ethyl 4-methyl-6-phenyl-2-thioxo-3,6-dihydro-1H-pyrimidine-5-carboxylate
- EU-006731
- Maybridge1_006365
- NCI60_014903
- NSC643910
- Oprea1_330764
- Pyrimidine-5-carboxilyc acid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-thioxo-, ethyl ester
- SBB016167
- 5-Pyrimidinecarboxylicacid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-thioxo-, ethyl ester
- ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE
- ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
- AURORA KA-3499
- BUTTPARK 61\40-96
- Pyrimidine-5-carboxilyc acid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-t hione-, ethyl ester
- 6-Methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
- 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- 5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-4
- Ethyl 6-methyl-4-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
- Ethyl 6-methyl-4-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin...
- 6-メチル-4-フェニル-2-チオキソ-1,2,3,4-テトラヒドロピリミジン-5-カルボン酸エチル