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AL-8810

AL-8810 化学構造式
246246-19-5
CAS番号.
246246-19-5
化学名:
AL-8810
别名:
(Z)-7-[(1R)-2β-[(1E,3R)-3-ヒドロキシ-3-(インダン-2-イル)-1-プロペニル]-3β-フルオロ-5α-ヒドロキシシクロペンチル]-5-ヘプテン酸;AL-8810;(5Z)-7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-ジヒドロ-1H-インデン-2-イル)-3-ヒドロキシプロパ-1-エン-1-イル]-3-フルオロ-5-ヒドロキシシクロペンチル]ヘプタ-5-エン酸
英語名:
AL-8810
英語别名:
AL 8810;AL-8810 >=98% (HPLC), solid;WTYSXBKKVNOOIX-JTGCGUAKSA-N;(5Z,13E)-(9S,11S,15R)-9,15,DIHYDROXY-11-FLUORO-15-(2-INDANYL)-16,17,18,19,20,PENTANOR-5,13-PROSTADIENOIC ACID;(5z, 13e)-(9s,11s,15r)-9,15,dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid;9ALPHA,15R-DIHYDROXY-11BETA-FLUORO-15-(2,3-DIHYDRO-1H-INDEN-2-YL)-16,17,18, 19,20-PENTANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;[1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid;5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-;[1R-[1ALPHA(Z),2BETA(1E,3S*),3BETA,5ALPHA]]-7-[3-FLUORO-5-HYDROXY-2-[3-HYDROXY-4-[2-(2,3-DIHYDRO-1H-INDENYL)]-1-BUTENYL]CYCLOLPENTYL]-5-HEPTENOIC ACID;[1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid, (5Z, 13E)-(9S,11S,15R)-9,15,Dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid
CBNumber:
CB0774936
化学式:
C24H31FO4
分子量:
402.5
MOL File:
246246-19-5.mol

AL-8810 物理性質

沸点 :
594.6±50.0 °C(Predicted)
比重(密度) :
1.21±0.1 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
DMSO: 10 mg/mL、可溶
外見 :
個体
酸解離定数(Pka):
4.76±0.10(Predicted)
色:
ホワイトからオフホワイト

安全性情報

WGK Germany  3

AL-8810 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CAY16735
AL 8810 		246246-19-5 1mg ￥29400 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01CAY16735
AL 8810 		246246-19-5 5mg ￥128500 2024-03-01 購入
Sigma-Aldrich Japan A3846 ≥98% (HPLC), solid
AL-8810 ≥98% (HPLC), solid		 246246-19-5 5mg ￥106000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01CAY16735
AL 8810 		246246-19-5 10mg ￥228500 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01CAY16735
AL 8810 		246246-19-5 25mg ￥499200 2024-03-01 購入

AL-8810 化学特性,用途語,生産方法

使用

AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this concentration, with EC50 values of approximately 430 nM. AL 8810 fully antagonized the bimatoprost-induced calcium mobilization in Swiss 3T3 fibroblasts at 100 μM, indicating that bimatoprost acts as an FP agonist in this preparation. The Ki for the inhibition of several potent agonists at the cloned human ciliary body FP receptor is in the range of 1-2 μM.

Biochem/physiol Actions

AL-8810 is a novel prostaglandin F2α analog; selective FP prostanoid receptor antagonist.

AL-8810 上流と下流の製品情報

原材料

準備製品

AL-8810 生産企業

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246246-19-5(AL-8810)キーワード:

フルオロシクロペンタン AL-8810
  • 246246-19-5
  • AL 8810
  • 9ALPHA,15R-DIHYDROXY-11BETA-FLUORO-15-(2,3-DIHYDRO-1H-INDEN-2-YL)-16,17,18, 19,20-PENTANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • (5Z,13E)-(9S,11S,15R)-9,15,DIHYDROXY-11-FLUORO-15-(2-INDANYL)-16,17,18,19,20,PENTANOR-5,13-PROSTADIENOIC ACID
  • [1R-[1ALPHA(Z),2BETA(1E,3S*),3BETA,5ALPHA]]-7-[3-FLUORO-5-HYDROXY-2-[3-HYDROXY-4-[2-(2,3-DIHYDRO-1H-INDENYL)]-1-BUTENYL]CYCLOLPENTYL]-5-HEPTENOIC ACID
  • (5z, 13e)-(9s,11s,15r)-9,15,dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid
  • [1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid, (5Z, 13E)-(9S,11S,15R)-9,15,Dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid
  • [1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid
  • WTYSXBKKVNOOIX-JTGCGUAKSA-N
  • 5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-
  • AL-8810 >=98% (HPLC), solid
  • (Z)-7-[(1R)-2β-[(1E,3R)-3-ヒドロキシ-3-(インダン-2-イル)-1-プロペニル]-3β-フルオロ-5α-ヒドロキシシクロペンチル]-5-ヘプテン酸
  • AL-8810
  • (5Z)-7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-ジヒドロ-1H-インデン-2-イル)-3-ヒドロキシプロパ-1-エン-1-イル]-3-フルオロ-5-ヒドロキシシクロペンチル]ヘプタ-5-エン酸
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