AL-8810
- CAS No.
- 246246-19-5
- Chemical Name:
- AL-8810
- Synonyms
- AL 8810;AL-8810 >=98% (HPLC), solid;WTYSXBKKVNOOIX-JTGCGUAKSA-N;(5Z,13E)-(9S,11S,15R)-9,15,DIHYDROXY-11-FLUORO-15-(2-INDANYL)-16,17,18,19,20,PENTANOR-5,13-PROSTADIENOIC ACID;(5z, 13e)-(9s,11s,15r)-9,15,dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid;9ALPHA,15R-DIHYDROXY-11BETA-FLUORO-15-(2,3-DIHYDRO-1H-INDEN-2-YL)-16,17,18, 19,20-PENTANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;[1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid;5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-;[1R-[1ALPHA(Z),2BETA(1E,3S*),3BETA,5ALPHA]]-7-[3-FLUORO-5-HYDROXY-2-[3-HYDROXY-4-[2-(2,3-DIHYDRO-1H-INDENYL)]-1-BUTENYL]CYCLOLPENTYL]-5-HEPTENOIC ACID;[1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid, (5Z, 13E)-(9S,11S,15R)-9,15,Dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid
- CBNumber:
- CB0774936
- Molecular Formula:
- C24H31FO4
- Molecular Weight:
- 402.5
- MDL Number:
- MFCD04039992
- MOL File:
- 246246-19-5.mol
- MSDS File:
- SDS
| Boiling point | 594.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 10 mg/mL, soluble |
| form | solid |
| pka | 4.76±0.10(Predicted) |
| color | white to off-white |
| FDA UNII | 12QE8J6004 |
AL-8810 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A3846 | AL-8810 ≥98% (HPLC), solid | 246246-19-5 | 5mg | $548 | 2024-03-01 | Buy |
| Cayman Chemical | 16735 | AL 8810 ≥98% | 246246-19-5 | 1mg | $105 | 2024-03-01 | Buy |
| Cayman Chemical | 16735 | AL 8810 ≥98% | 246246-19-5 | 5mg | $459 | 2024-03-01 | Buy |
| Cayman Chemical | 16735 | AL 8810 ≥98% | 246246-19-5 | 10mg | $816 | 2024-03-01 | Buy |
| Cayman Chemical | 16735 | AL 8810 ≥98% | 246246-19-5 | 25mg | $1783 | 2024-03-01 | Buy |
AL-8810 Chemical Properties,Uses,Production
Uses
AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this concentration, with EC50 values of approximately 430 nM. AL 8810 fully antagonized the bimatoprost-induced calcium mobilization in Swiss 3T3 fibroblasts at 100 μM, indicating that bimatoprost acts as an FP agonist in this preparation. The Ki for the inhibition of several potent agonists at the cloned human ciliary body FP receptor is in the range of 1-2 μM.
Definition
ChEBI: AL 8810 is a long-chain fatty acid.
Biological Activity
al-8810 is a novel prostaglandin f2α analog that acts as a selective antagonist of prostaglandin f2α (fp) receptor.prostaglandin receptors are a group of g-protein coupled receptor that exhibited a variety of functions in regulation of blood pressure and renal function; smooth muscle contraction; inhibition of plate aggregation; immune response etc.al-8810 has a ec50 of 261 ± 44 nm against fp receptor in the a7r5 rat thoracic aorta smooth muscle cells and a ec50 of 186 ± 63 nm in swiss mouse 3t3 fibroblasts. in addition, al-8810 antagonizes the response to 100 nm fluprostenol (ki = 426 ± 63 nm) in a concentration- dependent manner in a7r5 cells. [1]in the h-tm cells, al-8810 antagonizes the (±) fluprostenol-induced pi turn over responses concentration dependently (ki=2.56 ± 0.62 μm). al-8810 also antagonizes bimatoprost, travoprost acid, latanoprost acid and travoprost acid. [2] in hcm cells, 1 μm al-8810 blocks the 85% pgf2-induced mmp-2 secretion and 66% pgf2α-induced activation of erk1/2. [3]
Biochem/physiol Actions
AL-8810 is a novel prostaglandin F2α analog; selective FP prostanoid receptor antagonist.
References
1. griffin bw, klimko p, crider jy, sharif na. al-8810: a novel prostaglandin f2 alpha analog with selective antagonist effects at the prostaglandin f2 alpha (fp) receptor. j pharmacol exp ther. 1999 sep;290(3):1278-84.2. husain s, jafri f, crosson ce. acute effects of pgf2alpha on mmp-2 secretion from human ciliary muscle cells: a pkc- and erk-dependent process. invest ophthalmol vis sci. 2005 may;46(5):1706-13.3. sharif na, kelly cr, crider jy. human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other fp prostaglandin receptor agonist analogues. invest ophthalmol vis sci. 2003 feb;44(2):715-21.
AL-8810 Preparation Products And Raw materials
Raw materials
Preparation Products
AL-8810 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |