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プルバラノールB

プルバラノールB 化学構造式
212844-54-7
CAS番号.
212844-54-7
化学名:
プルバラノールB
别名:
2-クロロ-4-[[2-[[(R)-1-(ヒドロキシメチル)-2-メチルプロピル]アミノ]-9-イソプロピル-9H-プリン-6-イル]アミノ]安息香酸;2-[[(R)-1-イソプロピル-2-ヒドロキシエチル]アミノ]6-(3-クロロ-4-カルボキシアニリノ)-9-イソプロピル-9H-プリン;プルバラノールB;2-クロロ-4-[(2-{[(2R)-1-ヒドロキシ-3-メチルブタン-2-イル]アミノ}-9-(プロパン-2-イル)-9H-プリン-6-イル)アミノ]安息香酸
英語名:
(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
英語别名:
NG 95;CS-2003;PURVALANOL B;NG 95; NG95; NG-95;Purvalanol B, >=96%;Purvalanol B(NG 95);(R)-2-Chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzo;(R)-2-CHLORO-4-(2-(1-HYDROXY-3-METHYLBUTAN-2-YLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO)BENZOIC ACID;(2R)-2-((6-((3-Chloro-4-carboxyphenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol;(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
CBNumber:
CB1100440
化学式:
C20H25ClN6O3
分子量:
432.9
MOL File:
212844-54-7.mol

プルバラノールB 物理性質

融点 :
58.5 °C
沸点 :
660.6±65.0 °C(Predicted)
比重(密度) :
1.43±0.1 g/cm3(Predicted)
貯蔵温度 :
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解性:
DMSO: 37 mg/mL、可溶
外見 :
個体
酸解離定数(Pka):
2.81±0.25(Predicted)
InChIKey:
ZKDXRFMOHZVXSG-HNNXBMFYSA-N

安全性情報

WGK Germany  3

プルバラノールB 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC1581
Purvalanol B 		212844-54-7 10mg ￥77000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC1581
Purvalanol B 		212844-54-7 50mg ￥323000 2024-03-01 購入
Sigma-Aldrich Japan P5234 ≥97% (HPLC), solid
Purvalanol B ≥97% (HPLC), solid		 212844-54-7 1mg ￥12400 2024-03-01 購入

プルバラノールB 化学特性,用途語,生産方法

説明

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively). It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.

使用

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively). It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.

生物活性

Cyclin-dependent kinase inhibitor. IC 50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC 50 > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK.

プルバラノールB 上流と下流の製品情報

原材料

準備製品

プルバラノールB 生産企業

Global( 88)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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Biochempartner 		0086-13720134139
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CONIER CHEM AND PHARMA LIMITED 		+8618523575427
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career henan chemical co 		+86-0371-86658258 15093356674;
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InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
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ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131981 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15848 69

プルバラノールB  スペクトルデータ(1HNMR)

(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL(212844-54-7)1HNMR

212844-54-7(プルバラノールB)キーワード:

プルバラノールA ペルメトリン N,N-ジエチルベンズアミド 3-メチル-1-ブタノール 6-アニリノ-1H-プリン プルバラノールB
  • 212844-54-7
  • (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
  • PURVALANOL B
  • NG 95
  • (2R)-2-((6-((3-Chloro-4-carboxyphenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol
  • NG 95, (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
  • Purvalanol B, >=96%
  • (R)-2-Chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzo
  • Purvalanol B(NG 95)
  • (R)-2-CHLORO-4-(2-(1-HYDROXY-3-METHYLBUTAN-2-YLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO)BENZOIC ACID
  • CS-2003
  • NG 95; NG95; NG-95
  • Benzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-
  • 2-クロロ-4-[[2-[[(R)-1-(ヒドロキシメチル)-2-メチルプロピル]アミノ]-9-イソプロピル-9H-プリン-6-イル]アミノ]安息香酸
  • 2-[[(R)-1-イソプロピル-2-ヒドロキシエチル]アミノ]6-(3-クロロ-4-カルボキシアニリノ)-9-イソプロピル-9H-プリン
  • プルバラノールB
  • 2-クロロ-4-[(2-{[(2R)-1-ヒドロキシ-3-メチルブタン-2-イル]アミノ}-9-(プロパン-2-イル)-9H-プリン-6-イル)アミノ]安息香酸
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