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JZL 184 水和物

JZL 184 水和物 化学構造式
1101854-58-3
CAS番号.
1101854-58-3
化学名:
JZL 184 水和物
别名:
英語名:
JZL 184
英語别名:
CS-815;CS-1861;JZL 184;JZL-184; JZL 184;JZL 184 JZL184 JZL-184;JZL184 (with 15% inorganics);MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem;4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate;4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester
CBNumber:
CB12535677
化学式:
C27H24N2O9
分子量:
520.49
MOL File:
1101854-58-3.mol

JZL 184 水和物 物理性質

融点 :
116-120°C
沸点 :
706.4±60.0 °C(Predicted)
比重(密度) :
1.467±0.06 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
DMSO に可溶 (最大 25 mg/ml)。
外見 :
白からオフホワイトの固体
酸解離定数(Pka):
13.32±0.29(Predicted)
色:
薄黄色～黄緑色
安定性：:
購入日から2年間安定です。この DMSO 溶液は、-20°C で 2 か月間保存できます。
CAS データベース:
1101854-58-3
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
RIDADR  UN 2811 6.1 / PGIII
HSコード  29349990
絵表示（GHS） GHS hazard pictograms
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
注意書き
P301+P310 飲み込んだ場合：直ちに医師に連絡すること。

JZL 184 水和物 価格 もっと(7)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CAY13158
JZL 184 		1101854-58-3 5mg ￥12300 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01CAY13158
JZL 184 		1101854-58-3 10mg ￥20700 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01CAY13158
JZL 184 		1101854-58-3 100mg ￥154800 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC3836
JZL 184 		1101854-58-3 10mg ￥52000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC3836
JZL 184 		1101854-58-3 50mg ￥184000 2024-03-01 購入

JZL 184 水和物 化学特性,用途語,生産方法

説明

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.

使用

JZL 184 hydrate has been used as an inhibitor of monoacylglycerol lipase to study its effect on human osteoblast differentiation and proliferation and postsynaptic neurons.

Biochem/physiol Actions

JZL184 selectively inhibits MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes. JZL 184 is the first selective inhibitor of MAGL with nanomolar portency and over 200-fold selectivity for MAGL vs FAAH. When administered to mice, JZL184 increased levels of 2-arachidonoylglycerol in the brain by about 8-fold, with no effect on levels of anandamide.

JZL 184 水和物 上流と下流の製品情報

原材料

準備製品

JZL 184 水和物 生産企業

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JZL 184 水和物  スペクトルデータ(1HNMR)

JZL 184(1101854-58-3)1HNMR

1101854-58-3(JZL 184 水和物)キーワード:

3-[[[3-[(E)-2-(7-クロロキノリン-2-イル)エテニル]フェニル][[3-(ジメチルアミノ)-3-オキソプロピル]チオ]メチル]チオ]プロパン酸 N-フェニル-4-(3-キノリルメチル)-1-ピペラジンカルボアミド N-アラキドニルマレイミド BORTEZOMIB (VELCADE) 臭化チオトロピウム HYDRATE URB-597 OTX 015 ダクトリシブ
  • 1101854-58-3
  • 4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate
  • 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester
  • 1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester
  • 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester JZL 184
  • JZL 184
  • JZL 184 JZL184 JZL-184
  • MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem
  • JZL-184; JZL 184
  • CS-815
  • CS-1861
  • JZL 184 ?JZL184 ?JZL-184 ?(4-Nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
  • 1-Piperidinecarboxylicacid,4-Chemicalbook[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-,4-nitrophenylester
  • JZL184 (with 15% inorganics)
  • 4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate
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