N-(4-ベンジルピペラジン-1-イル)-1-(3,5-ジメチル-1-フェニル-1H-ピラゾール-4-イル)メタンイミン

N-(4-ベンジルピペラジン-1-イル)-1-(3,5-ジメチル-1-フェニル-1H-ピラゾール-4-イル)メタンイミン 価格 もっと(12)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1974	SANT-1	304909-07-7	50mg	￥290000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCS115000	SANT-1	304909-07-7	100mg	￥242800	2023-06-01	購入
Sigma-Aldrich Japan	S4572	≥98% (HPLC), powder SANT-1 ≥98% (HPLC), powder	304909-07-7	5mg	￥37300	2024-03-01	購入
Sigma-Aldrich Japan	S4572	≥98% (HPLC), powder SANT-1 ≥98% (HPLC), powder	304909-07-7	25mg	￥125000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01W0119-1635	98.0+% (HPLC) SANT-1 98.0+% (HPLC)	304909-07-7	5mg	￥25500	2024-03-01	購入

N-(4-ベンジルピペラジン-1-イル)-1-(3,5-ジメチル-1-フェニル-1H-ピラゾール-4-イル)メタンイミン 化学特性,用途語,生産方法

外観

白色〜黄色, 結晶〜粉末

溶解性

メタノールに溶ける。

説明

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC₅₀ = 20 nM). It counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO. SANT 1 targets inactive SMO while it is in the cytoplasm, before it relocates to the primary cilium and is activated. Through antagonism of SMO, SANT 1 represses Gli-mediated transcription in a variety of cell types.

化学的特性

Pale Yellow Solid

使用

Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells² and chronic lymphocytic leukemia cells³ with SANT-1 induced cell death.

生物活性

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K D = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM (in Shh-LIGHT2 cells).

N-(4-ベンジルピペラジン-1-イル)-1-(3,5-ジメチル-1-フェニル-1H-ピラゾール-4-イル)メタンイミン 上流と下流の製品情報

原材料

準備製品

N-(4-ベンジルピペラジン-1-イル)-1-(3,5-ジメチル-1-フェニル-1H-ピラゾール-4-イル)メタンイミン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

304909-07-7(N-(4-ベンジルピペラジン-1-イル)-1-(3,5-ジメチル-1-フェニル-1H-ピラゾール-4-イル)メタンイミン)キーワード:

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• 304909-07-7
• N-[(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHYLENE]-4-(PHENYLMETHYL)-1-PIPERAZINAMINE
• SANT-1
• (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
• 1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-
• (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
• SANT1 10MG
• SANT1;SANT 1
• SANT-1 - CAS 304909-07-7 - Calbiochem
• CS-1685
• SANT-1; SANT1;SANT 1
• SANT-1 (This product is only available in Japan.)
• N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
• SANT-1 USP/EP/BP
• SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit
• N-(4-ベンジルピペラジン-1-イル)-1-(3,5-ジメチル-1-フェニル-1H-ピラゾール-4-イル)メタンイミン