ベンゾイミダゾール 化学特性,用途語,生産方法
外観
白色～褐色, 結晶～結晶性粉末
溶解性
エタノールに可溶、水, エーテルに難溶、希酸, 強アルカリに可溶、ベンゼン, 石油エーテルに不溶。
解説
1H-benzimidazole．C7H6N2(118.13)．ベンゾイミダゾールは，o-フェニレンジアミンにクロロホルムとアルコール性カリとの作用，またはギ酸と塩酸とともに煮沸することによって得られる．無色の板状晶．融点170 ℃，沸点 ＞ 360 ℃．pKa 5.48．λmax 243，275 nm(ε 6166，3802)．エタノール，塩酸，アルカリ水溶液に可溶，冷水，エーテル，ベンゼンに難溶．過マンガン酸カリウムで酸化すると，シュウ酸と少量のイミダゾールジカルボン酸とが得られる．森北出版「化学辞典（第2版）
用途
有機合成原料、生理作用研究用。
化学的特性
white crystals
使用
Usually used as template compound in the preparation of molecularly imprinted polymer via electropolymerization and electrodeposition of pyrrole on a pencil graphite electrode,and also used in the preparation of benzimidazolium surfactant, 1-hexadecyl-1H-benzimidazole.
一般的な説明
White tabular crystals.
空気と水の反応
Insoluble in water.
反応プロフィール
An amine. Neutralizes acids to form salts plus water. These acid-base reactions are exothermic. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. May be shock sensitive.
健康ハザード
ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzimidazole emits highly toxic fumes.
火災危険
Flash point data for Benzimidazole are not available. Benzimidazole is probably combustible.
薬理学
The mode of action of benzimidazoles has been described
in several comprehensive reviews (1,32,33). The primary
mode of action of benzimidazoles has been identified as
the specific binding to the β-subunit of fungal tubulin and,
consequently, an interference with microtubule assembly.
Microtubules are major components of the fungal
cytoskeleton and are involved in meiosis and mitosis, both
of which are blocked in the presence of benzimidazoles.
安全性プロファイル
Poison by intravenous
and intraperitoneal routes. Moderately toxic
by ingestion. Mutation data reported. When
heated to decomposition it emits highly
toxic fumes of NOx.
純化方法
It crystallises from water or aqueous EtOH (charcoal) and is dried at 100o for 12hours. [Beilstein 23 H 131, 23/6 V 196.]
ベンゾイミダゾール 上流と下流の製品情報
原材料
準備製品