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1H-벤즈아미다졸

1H-벤즈아미다졸
1H-벤즈아미다졸 구조식 이미지
카스 번호:
51-17-2
한글명:
1H-벤즈아미다졸
동의어(한글):
벤조이미다졸;1H-벤즈아미다졸;벤즈이미다졸
상품명:
Benzimidazole
동의어(영문):
BZI;nsc759;Azindol;NSC 759;Azindole;AKOS BBS-0;3-Azaindole;Benzimidazol;BENZIMIDAZOLE;BenziMedazole
CBNumber:
CB2177003
분자식:
C7H6N2
포뮬러 무게:
118.14
MOL 파일:
51-17-2.mol

1H-벤즈아미다졸 속성

녹는점
169-171 °C (lit.)
끓는 점
360 °C
밀도
1.1151 (rough estimate)
굴절률
1.5500 (estimate)
인화점
360°C
저장 조건
Store below +30°C.
용해도
xylene: soluble1g in 2g (boiling)(lit.)
물리적 상태
Crystalline Powder or Crystals
산도 계수 (pKa)
5.532(at 25℃)
색상
Beige to brown
수용성
sparingly soluble
최대 파장(λmax)
271nm(MeOH)(lit.)
Merck
14,1081
BRN
109682
안정성
Stable. Combustible. Incompatible with strong oxidising agents.
InChIKey
HYZJCKYKOHLVJF-UHFFFAOYSA-N
CAS 데이터베이스
51-17-2(CAS DataBase Reference)
NIST
1H-Benzimidazole(51-17-2)
EPA
Benzimidazole (51-17-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 37/39-26-24/25
WGK 독일 3
RTECS 번호 DD5425000
위험 참고 사항 Irritant
TSCA Yes
HS 번호 29339990
유해 물질 데이터 51-17-2(Hazardous Substances Data)
독성 LD50 oral in mouse: 2910mg/kg
기존화학 물질 KE-02674
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
예방조치문구:

1H-벤즈아미다졸 MSDS


Benzimidazole

1H-벤즈아미다졸 C화학적 특성, 용도, 생산

용도

벤즈 이미 다졸은 살충제 중간체, 살균제 중간체 및 트리아 졸 살균제로 사용할 수 있습니다.

포장, 보관 및 운송

사용하지 않을 때는 뚜껑을 닫아 보관하십시오. 밀폐 된 용기에 보관합니다. 상반되는 물질에서 떨어져 있 차갑고, 건조하고 환기가 잘되는 곳에 보관하십시오.

화학적 성질

white crystals

용도

Usually used as template compound in the preparation of molecularly imprinted polymer via electropolymerization and electrodeposition of pyrrole on a pencil graphite electrode,and also used in the preparation of benzimidazolium surfactant, 1-hexadecyl-1H-benzimidazole.

용도

Benzimidazole is a building block for making anthelmintic drugs like albendazole, mebendazole and triclabendazole and anti-ulcer drugs like pantoprazole, rabeprazole, lansoprazole and omeprazole. It is used in the preparation of pyrene derived benzimidazole linked polymers (BILPs), which are used for selective carbon dioxide separation applications due to their properties like porous materials, regenerability and sorbent selection parameters.

일반 설명

White tabular crystals.

공기와 물의 반응

Insoluble in water.

반응 프로필

An amine. Neutralizes acids to form salts plus water. These acid-base reactions are exothermic. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. May be shock sensitive.

건강위험

ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzimidazole emits highly toxic fumes.

화재위험

Flash point data for Benzimidazole are not available. Benzimidazole is probably combustible.

Pharmacology

The mode of action of benzimidazoles has been described in several comprehensive reviews (1,32,33). The primary mode of action of benzimidazoles has been identified as the specific binding to the β-subunit of fungal tubulin and, consequently, an interference with microtubule assembly. Microtubules are major components of the fungal cytoskeleton and are involved in meiosis and mitosis, both of which are blocked in the presence of benzimidazoles.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits highly toxic fumes of NOx.

Purification Methods

It crystallises from water or aqueous EtOH (charcoal) and is dried at 100o for 12hours. [Beilstein 23 H 131, 23/6 V 196.]

1H-벤즈아미다졸 준비 용품 및 원자재

원자재

준비 용품


1H-벤즈아미다졸 공급 업체

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