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タリペキソール

タリペキソール 化学構造式
101626-70-4
CAS番号.
101626-70-4
化学名:
タリペキソール
别名:
6-アリル-2-アミノ-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピン;タリペキソール;6-アリル-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピン-2-アミン;5,6,7,8-テトラヒドロ-6-(2-プロペニル)-4H-チアゾロ[4,5-d]アゼピン-2-アミン;2-アミノ-6-アリル-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピン
英語化学名:
TALIPEXOLE
英語别名:
Domin;Talipexol;TALIPEXOLE;Talipexolum;Talipexolum [latin];Talipexol [spanish];TALIPEXOLE USP/EP/BP;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
CBNumber:
CB3153213
化学式:
C10H15N3S
分子量:
209.31
MOL File:
101626-70-4.mol

タリペキソール 物理性質

沸点 :
364.6±37.0 °C(Predicted)
比重(密度) :
1.167±0.06 g/cm3(Predicted)
酸解離定数(Pka):
7.22±0.20(Predicted)

安全性情報

タリペキソール 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

タリペキソール 化学特性,用途語,生産方法

効能

パーキンソン病治療薬, ドパミンD2受容体作動薬

説明

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

Originator

Boehringer Ingelheim (Germany)

brand name

Domin

タリペキソール 上流と下流の製品情報

原材料

準備製品


タリペキソール 生産企業

Global( 31)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132148 58
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1938 70
BOC Sciences 16314854226
info@bocsci.com United States 21113 65
MedChemexpress LLC 609-228-6898
609-228-5909 sales@medchemexpress.com United States 4788 58
LETOPHARM LIMITED +86-21-5821 5861
+86-21-5106 2861 sales@letopharm.com China 2388 58
Musechem +1-800-259-7612
+1-800-259-7612 info@musechem.com United States 4665 60
Jinan blalong chemical co. LTD 2710913286@qq.com
1513643261@qq.com China 18596 58

101626-70-4(タリペキソール)キーワード:


  • 101626-70-4
  • TALIPEXOLE
  • 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine
  • Domin
  • 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine
  • 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine
  • Talipexol
  • Talipexol [spanish]
  • Talipexolum
  • Talipexolum [latin]
  • 4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-
  • TALIPEXOLE USP/EP/BP
  • 6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
  • 6-アリル-2-アミノ-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピン
  • タリペキソール
  • 6-アリル-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピン-2-アミン
  • 5,6,7,8-テトラヒドロ-6-(2-プロペニル)-4H-チアゾロ[4,5-d]アゼピン-2-アミン
  • 2-アミノ-6-アリル-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピン
  • Parkinson病治療薬
  • αアドレナリン作動薬
  • ドーパミン作動薬
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