アプロチニン溶液 化学特性,用途語,生産方法
外観
無色〜ほとんど無色, 澄明の液体
溶解性
水に溶ける。
特長
エンドトキシン試験済み
使用上の注意
安定性中性～酸性溶液中、高い温度で安定。pH＞12以上のアルカリ溶液で不可逆的に変性する。8mol/l尿素で部分的・可逆的に変性する。
説明
Aprotinin is a reversible inhibitor of serine proteases such as trypsin (K
i = 0.06 pM), chymotrypsin (K
i = 9.5 nM), and kallikrein (K
i = 0.8 nM). It is a much weaker inhibitor of thrombin (K
i = 0.1-
0.8 mM) and trypsinogen (K
i = 2 μM). Aprotinin also competitively inhibits nNOS and iNOS with K
i values of 50 and 78 μM, respectively. Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
化学的特性
white powder
使用
Aprotinin is largely used as an inhibitor of trypsin.
一般的な説明
Trypsin inhibitor, pancreas type from bovine lung. It is known as Pancreatic trypsin inhibitor (BPTI). Aprotinin, also known as pancreatic trypsin inhibitor and trypsin-kallikrein inhibitor, is found to be expressed in lungs, spleen, liver, and pancreas. It is also found to be present in the free form in calf serum.
安全性プロファイル
Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.
アプロチニン溶液 上流と下流の製品情報
原材料
準備製品