ChemicalBook
Chinese english Germany Korea

ピペリジン

ピペリジン 化学構造式
110-89-4
CAS番号.
110-89-4
化学名:
ピペリジン
别名:
ピペリジン;ペンタメチレンイミン;ヘキサザン;ヘキサヒドロピリジン;シペンチル;シクロペンチミン
英語化学名:
Piperidine
英語别名:
PIP;PPR;Hexazane;Cypentil;Piperdine;Piperidin;FEMA 2908;PIPERIDINE;PIPERIDINE GR;perhydroazine
CBNumber:
CB3761009
化学式:
C5H11N
分子量:
85.15
MOL File:
110-89-4.mol

ピペリジン 物理性質

融点 :
-11 °C
沸点 :
106 °C(lit.)
比重(密度) :
0.930 g/mL at 20 °C
蒸気密度:
3 (vs air)
蒸気圧:
23 mm Hg ( 20 °C)
屈折率 :
n20/D 1.452(lit.)
FEMA :
2908 | PIPERIDINE
闪点 :
16 °C(lit.)
貯蔵温度 :
Store in dark!
溶解性:
miscible in water and alcohol; soluble in ether, acetone, benzene and chloroform maximum allowable concentration: not established; more toxic, irritating and volatile than pyridine (Reinhardt and Brittelli 1981).
酸解離定数(Pka):
11.123(at 25℃)
PH:
12.6 (100g/l, H2O, 20°C)
爆発限界(explosive limit):
1.5-10.3%(V)
水溶解度 :
Miscible
Sensitive :
Air Sensitive
JECFA Number:
1607
Merck :
14,7468
BRN :
102438
安定性::
Stable. Highly flammable. Incompatible with strong oxidizing agents, strong acids, organic acids, water. Vapours may flow along surfaces to a distant source of ignition.
CAS データベース:
110-89-4(CAS DataBase Reference)
NISTの化学物質情報:
Piperidine(110-89-4)
EPAの化学物質情報:
Piperidine(110-89-4)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,F
Rフレーズ  61-10-20/21-34-23/24-11-52-24-20/22
Sフレーズ  53-16-26-36/37/39-45-27
RIDADR  UN 3286 3/PG 2
WGK Germany  3
RTECS 番号 TM3500000
3-34
自然発火温度 320 °C
TSCA  Yes
国連危険物分類  8
容器等級  I
HSコード  29333210
有毒物質データの 110-89-4(Hazardous Substances Data)
毒性 LD50 orally in rats: 0.52 ml/kg (Smyth)
消防法 危険物第4類第一石油類(水溶性)
化審法 一般化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H331 吸入すると有毒 急性毒性、吸入 3 危険 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

ピペリジン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ピペリジン 化学特性,用途語,生産方法

外観

無色~ほとんど無色, 澄明の液体

溶解性

水に混和, アルコール, エーテル, ベンゼン, クロロホルムに可溶。水に極めて溶けやすく、エタノールに溶ける。

用途

染色、医薬原料、ゴム薬品

用途

ペプチド合成用溶媒。

用途

ゴムの加硫促進剤や血管拡張剤原料の製造、溶剤など、溶剤、エポキシ樹脂硬化剤など

使用上の注意

不活性ガス封入

化学的特性

Clear or slightly yellow liquid

化学的特性

Piperidine is a clear, colorless liquid. Pepper, ammonia or amine odor.

化学的特性

Piperidine is a strong base (pKb = 2.88) that reacts vigorously with oxidizing materials, is easily ignited, and forms explosive vapor concentrations at room temperature. When heated to decomposition it gives off toxic fumes of NOx (Sax 1984). It behaves like an aliphatic secondary amine and can form complexes with salts of heavy metals (HSDB 1988).

化学的特性

Piperidine has a heavy, sweet, floral, animal odor and a burning peppery taste.

天然物の起源

Piperidine occurs at low levels in a variety of food products (Neurath et al 1977), including baked ham (0.2 p.p.m.), milk (0.11 p.p.m.) coffee (1 p.p.m. dry) (Singer and Lijinsky 1976) and canned fish (Tanikawa and Motohiro 1960). It is also found in black pepper (Windholz 1983), hemp (Obata and Ishikawa 1960), hemlock (Cromwell 1956) and tobacco (Furia and Bellanca 1975). Piperidine is a natural constituent of skin (Sax and Lewis 1987), human urine (Von Euler 1944), brain (Honegger and Honegger 1960) and cerebrospinal fluid (Perry et al 1964). Humans excrete about 3-20 mg/d in the urine (Reinhardt and Britelli 1981).

使用

It is used in organic synthesis, especially inthe preparation of many crystalline derivativesof aromatic nitro compounds.

使用

Fits Applied Biosystems 431 and 433A peptide synthesizers.

使用

Piperidine is an organic heterocyclic amine widely used as building block and reagent in the synthesis of organic compounds including pharmaceuticals.

定義

ChEBI: An azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. It is a metabolite of cadaverine, a polyamine found in the human intestine.

製造方法

Usually prepared by electrolytic reduction of pyridine.

定義

piperidine: A saturated heterocycliccompound having a nitrogen atom ina six-membered ring, C5H11N; r.d.0.86; m.p. –7°C; b.p. 106°C. The structureis present in many alkaloids

調製方法

Piperidine is usually prepared by the electrolytic reduction of pyridine. It may also be obtained by heating piperidine with alcoholic KOH or by the cyclization of 1,5-diaminopentane hydrochloride (Windholz 1983). U.S. production in 1983 was approximately 606,000 pounds (HSDB 1988). Commercial piperidine is supplied in two grades, 95 and 98 percent pure (Sax and Lewis 1987).

brand name

Cypentil (Abbott).

Aroma threshold values

Detection: 65.8 to 70.6 ppm

一般的な説明

A clear colorless liquid with a pepper-like odor. Less dense than water, but miscible in water. Will float on water. Flash point 37°F. Melting point -15.8°F (-9°C). Boiling point 222.8°F (106°C). May severely irritate skin and eyes. May be toxic by ingestion and inhalation. Vapors heavier than air. Used to make rubber and as a solvent.

空気と水の反応

Highly flammable. Miscible in water.

反応プロフィール

1-Oxa-4-azacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

健康ハザード

Strong local irritant and may cause permanent injury after short exposure to small amounts. Ingestion may involve both irreversible and reversible changes. 30 to 60 mg/kg may cause symptoms in humans.

健康ハザード

Piperidine is a highly toxic compound. Theacute oral toxicity is high in many species oftest animals. The oral LD50 values in miceand rabbits are 30 and 145 mg/kg, respectively(NIOSH 1986). The liquid is moderatelytoxic by skin absorption. Inhalationtoxicity in experimental animals was low,however. A 4-hour exposure to 4000 ppmwas lethal to rats. Piperidine is corrosive toskin. Contact with eyes can produce severeirritation.

健康ハザード

An irritation threshold of 26 p.p.m. has been reported from studies on human volunteers (Bazarova and Migukina 1975). Levels of 2 to 5 p.p.m. in air have been recorded during the transfer of piperidine from drums in a semi-closed system. At this level, the vapors were intolerable but no irritation was observed (ANON 1982). In an accidental case of skin exposure, third-degree burns developed after only 3 min of skin contact (Linch 1965). Piperidine has a pronounced emetic effect in humans. When administered to schizophrenic patients at doses of 1 to 6 g/d, it was shown to cause nausea and a subjective sense of well being (Giacobini 1976; Tasher et al 1960). The primary, but low-level, means of human exposure, however, is from the natural piperidine content of foods (HSDB 1988).

火災危険

1-Oxa-4-azacyclohexane evolves explosive concentrations of vapor at normal room temperatures. When heated to decomposition, 1-Oxa-4-azacyclohexane emits highly toxic fumes of nitrogen oxides. Dangerous, when exposed to heat, flame, or oxidizers. Avoid 1-Perchloryl1-Oxa-4-azacyclohexane and oxidizing materials. 1-Oxa-4-azacyclohexane is a reactive compound and forms complexes with the salts of heavy metals. 1-Oxa-4-azacyclohexane evolves explosive concentrations of vapor at normal room temperatures. Keep away from igniting sources and heat.

工業用途

Piperidine is used as a solvent, a curing agent for rubber and epoxy resins, a catalyst in silicone esters, an intermediate in organic synthesis and as a complexing agent (HSDB 1988; Reinhardt and Britelli 1981). It is a trace constituent in oils and fuels (Sax and Lewis 1987). It is used in the manufacture of local anesthetics, analgesics and other pharmaceuticals, and also for wetting agents and germicides (Gehring 1983). It is also used as a flavor additive in soups, meats, condiments, baked goods, candy and non-alcoholic beverages at 0.05-5.0 p.p.m. (Furia and Bellanca 1975).

安全性プロファイル

Poison by ingestion, skin contact, and intraperitoneal routes. Moderately toxic by subcutaneous route. Mildly toxic by inhalation. An experimental teratogen. Experimental reproductive effects by inhalation. A skin irritant. Mutation data reported. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Can react vigorously with oxidzing materials. To fight fire, use alcohol foam, CO2, dry chemical. Explodes on contact with 1- perchloryl-piperidme, dqanofurazan, N- nitrosoacetadde. When heated to decomposition it emits highly toxic fumes of NOx. Used in agriculture and pharmaceuticals, and as an intermediate for rubber accelerators. Used in production of drugs of abuse.

職業ばく露

Piperidine is used in agriculture and pharmaceuticals; intermediate for rubber accelerators; as a solvent; as a curing agent for rubber and epoxy resins; catalyst for condensation reactions; as an ingredient in oils and fuels; complexing agent; manufacture of local anesthetics; in analgesics; pharmaceuticals, wetting agents; and germicides; synthetic flavoring. Not registered as a pesticide in the Unied States.

代謝

Piperidine is readily absorbed through the gastrointestinal tract, skin and lungs (HSDB 1988). In hens, 35 to 70% of an injected dose is rapidly excreted unchanged in the urine (Williams 1959; Sperber 1949). Rabbits also excrete piperidine unchanged (Hildebrandt 1900). When injected intraventricularly into rats, piperidine disappeared exponentially with a half-life of 20 min (Meek 1973). In a more recent study, Okano et al (1978) found that in rats most of an i.p. dose of [3H]-piperidine was excreted unchanged. Two major metabolites were identified as 3- and 4-hydroxypiperidine. Both compounds were also found in untreated animals and thus are probably metabolites of piperidine of exogenous or endogenous origin. These metabolites represent a detoxification mechanism, since they lack the potent pharmacological activities of the parent compound. Two unidentified metabolites were assumed to be conjugates. In a much earlier study, Novello et al (1926) claimed that piperidine was excreted as the ethereal sulfate. Metabolic studies of analgesics and anesthetics containing the piperidine ring have demonstrated the occurrence of N-hydroxylation, formation of a 6-oxo-derivative, and C-oxidative ring cleavage (Oelschlager and Al Shaik 1985). N-nitrosopiperidine has been synthesized from piperidine and sodium nitrite in the gastric contents,R.L. Reed isolated stomach and isolated small intestine of rats (Alam et al 1971; Epstein 1972).

輸送方法

UN2401 Piperidine, Hazard Class: 8; Labels: 8-Corrosive material, 3-Flammable liquid.

純化方法

Dry piperidine with BaO, KOH, CaH2, or sodium, and fractionally distil (optionally from sodium, CaH2, or P2O5). Purify from pyridine by zone melting. [Beilstein 22 H 6, 22

不和合性

Piperidine is a highly flammable liquid. Vapor may form explosive mixture with air (at room temperature). A medium-strong base. Reacts violently with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Piperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

ピペリジン 上流と下流の製品情報

原材料

準備製品

2-アミノ-4,5,6,7-テトラヒドロベンゾ[b]チオフェン-3-カルボン酸エチル 2-アミノ-5-ニトロピリミジン 2,4,5-トリメトキシけい皮酸 ジペンタメチレンチウラムテトラスルフィド 6-ブロモ-3-ブチリル-2H-クロメン-2-オン 2クロロ6メチル3ピリジンカルボニトリル 2-アミノ-4-エチル-5-メチルチオフェン-3-カルボン酸メチル 1,2,3,5-テトラヒドロ-8-チア-5,7-ジアザ-シクロペンタ[A]インデン-4-オン 3,4-メチレンジオキシけい皮酸 クロペラスチン 3-ピリジン-2-イルプロパン酸 5-メチル-4-イソオキサゾールスルホニルクロリド 3-アセトアミドクマリン 3-(トリフルオロメトキシ)けい皮酸 2-アミノ-6-メチル-4,5,6,7-テトラヒドロベンゾ[B]チオフェン-3-カルボン酸アミド 2,3-ナフタレンジアルデヒド ベンプロペリンリン酸塩 4-エトキシけい皮酸 3-(3,5-ジメトキシフェニル)プロペン酸 ジフェニドール塩酸塩 4-フルオロけい皮酸 トルペリゾン 塩酸塩 1-(2-アミノエチル)ピペリジン 1-ピペリジンペンタノール 5-ブロモ-2-フルオロ桂皮酸 臭化物 ミノキシジル シリンガアルデヒド 6-クロロ-2-オキソ-2H-クロメン-3-カルボン酸 2-アミノ-5,6-ジヒドロ-4H-シクロペンタ[B]チオフェン-3-カルボン酸エチルエステル 3,5-ジメトキシ-4-ヒドロキシけい皮酸 2-アミノ-5,6-ジヒドロ-4H-シクロペンタ[B]チオフェン-3-カルボン酸メチル 3-(3-メチル-2-チエニル)アクリル酸

ピペリジン 生産企業

Global( 0)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度

110-89-4(ピペリジン)キーワード:


  • 110-89-4
  • 3H-Spiro[2-benzofuran-1,4'
  • azocyclohexane
  • Cypentil
  • hexahydroazine
  • Hexahydropyridin
  • hexahydro-pyridin
  • hexahydropyridinepentamethyleneimine
  • Hexazane
  • Pentamethyleneamine
  • PIPERIDINE R. G., REAG. PH. EUR.
  • PIPERIDINE, 99%, BIOTECH GRADE
  • PIPERIDINE 99+% FCC
  • PIPERIDINE 99.5+% BIOTECH GRADE
  • Piperidine/Hexahydropyridine
  • 1,2-Dihydro-1'
  • PIPERIDINE FOR SYNTHESIS
  • PIPERIDINE GR
  • Piperidine, 20% in N-Methylpyrrolidone, for peptide synthesis
  • Piperidine, extra pure, 99%
  • PIPERIDINE,REAGENT
  • 5-Chloro-3,4-dihydro-spiro[chromene-2,4’
  • PIPERIDINE (PEPTIDE GRADE)
  • 1-Oxa-4-azacyclohexane
  • PIPERIDINE PIPERIDINE
  • (R)-1-BENZYL-PIPERIDINE-3-CARBOXYLIC ACID
  • (R)-N-BOC-ETHYL PIPERIDINE-3-CARBOXYLATE
  • (S)-1-BENZYL-PIPERIDINE-3-CARBOXYLIC ACID
  • (S)-N-BOC-ETHYL PIPERIDINE-3-CARBOXYLATE
  • Piperdine
  • Polypropylene random copolymer
  • ピペリジン
  • ペンタメチレンイミン
  • ヘキサザン
  • ヘキサヒドロピリジン
  • シペンチル
  • シクロペンチミン
  • 代謝産物
Copyright 2017 © ChemicalBook. All rights reserved