3-クロロプロピオニトリル 化学特性,用途語,生産方法
外観
無色～わずかにうすい赤褐色, 澄明の液体
溶解性
水に難溶。エタノール, アセトンに易溶。エタノール及びアセトンに極めて溶けやすく、水に溶けにくい。
用途
医薬、高分子の合成原料
用途
有機合成原料(医薬、ポリマー)。
化学的特性
3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor
使用
In pharmaceutical and polymer synthesis. Combines the reactivity of a nitrile and an alkyl halide. Because of the cyano group the chlorine atom is more reactive than in ordinary alkyl halides.
調製方法
3-Chloropropionitrile [542-76-7], 3-chloropropanenitrile, b-chloropropionitrile, ClCH2 CH2CN, Mr 89.53, mp-51℃, bp 175 –176℃ (101.3 kPa), n20D 1.4360, d204 1.1573, is a colorless liquid miscible with acetone, benzene, ethanol and diethyl ether. It can be obtained by hydrochlorination of acrylonitrile with hydrochloric acid [49] and is used as an organic intermediate in the synthesis of the H2-receptor famotidine.
一般的な説明
Colorless liquid with a characteristic acrid odor. Used in pharmaceutical and polymer synthesis.
反応プロフィール
Toxic gas (hydrogen chloride) is released when the compound is heated above 266 F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat. [EPA, 1998].
危険性
Toxic by ingestion, inhalation, and skin
contact. Combustible.
健康ハザード
Toxic effects are a result of systemic cyanide poisoning. (Non-Specific -- Cyanide) Few poisons are more rapidly lethal. Average oral lethal dose for hydrogen cyanide is approximately 60-90 mg (corresponds to 200 mg of potassium cyanide). Cause of death is lack of oxygen to the body's cells (especially the brain and heart) as a result of the chemical inhibiting cell enzymes.
火災危険
Toxic gas (hydrogen chloride) is released when the compound is heated above 266F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat.
職業ばく露
This material is used in pharmaceutical manufacture and in polymer synthesis.
輸送方法
UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
不和合性
Contact with strong oxidizers may cause a fire and explosion hazard
3-クロロプロピオニトリル 上流と下流の製品情報
原材料
準備製品