塩化メチル水銀 化学特性,用途語,生産方法
性質
chloromercurimethane．CH3HgCl(251.08)．クロロメチル水銀ともいう．無水酢酸と過酸化水素から調製した (CH3COO)2 に酢酸水銀と塩化カルシウムを加え，酢酸中で加熱して合成する．塩化メチル水銀, 白色の結晶．融点172 ℃．水に対する溶解度は常温で5000 ppm．環境基準では，公共用水域において検出されてはいけないとされており，測定には高感度のECD(電子捕獲)法検出器をもつガスクロマトグラフィーが使用される(検出限界0.5 ppb)．LD50 30 mg/kg(マウス，経口)．森北出版「化学辞典（第2版）
毒性
塩化メチル水銀, アルキル水銀の一種で，無機水銀に比べて体内に蓄積されやすく，中枢神経などに作用して高い毒性を示す．1950～1960年代に熊本県水俣湾沿岸地域や新潟県阿賀野川流域で発生した水俣病の原因物質でもある．いずれも，アセチレンからアセトアルデヒド製造時に触媒として使われた無機水銀HgSO4から生成したものと考えられている．
化学的特性
white crystals or powder
使用
Methylmercury(II) chloride is used as a precursor for the preparation of methyl mercury acetate. It is used as a specific reagent (electron stain) for sulfhydryl groups in biological materials like protein as well as demonstration in electron microscopy.
一般的な説明
White microcrystals or crystals.
空気と水の反応
Aqueous solutions at a concentration of 0.25 mg / mL are stable for 3 weeks in the dark at room temperature. Aqueous 0.0001 M solutions show no degradation after 17.1 hours of midday sunlight. High intensity UV irradiation of solutions causes decomposition .
反応プロフィール
METHYLMERCURY(II) CHLORIDE may be sensitive to light.
火災危険
Flash point data for METHYLMERCURY(II) CHLORIDE are not available; however, METHYLMERCURY(II) CHLORIDE is probably nonflammable.
安全性プロファイル
Poison by ingestion,
intramuscular, intravenous, and intraperitoneal routes. Questionable
carcinogen with experimental carcinogenic
and teratogenic data. Human mutation data
reported. Experimental reproductive effects.
When heated to decomposition it emits very
toxic fumes of Cland Hg. See also
MERCURY COMPOUNDS.
発がん性
A number of authors have reported carcinogenic effects in
rats and mice exposed orally to methylmercury. An association
between methylmercury exposure and renal adenocarcinoma
was shown in male mice, but no increase in tumor
incidence was detected in rats. These findings are supported
by reports on methylmercury-induced degeneration of DNA,
and inhibition of the formation of the mitotic spindle.
Intoxications with alkoxialkyl or aryl compounds are similar
to intoxications with inorganic mercury compounds, as
these organomercurials are relativelyunstable. Alkylmercury
compounds, such as methylmercury, result in a different
syndrome due to the stability of the mercury–methyl binding.
The earliest symptoms in adults are paresthesias in the
extremities and the face, particularly around the mouth.
Later on, disturbances occur inthe motor functions, resulting
in ataxia and dysphasia. The visual field is decreased, and,
in severe cases, may result in total blindness. These symptoms
were observed in large-scale poisonings caused by
methylmercury.
純化方法
Recrystallise it from absolute EtOH (20mL/g). at 206nm ( 1.37). [See EtHgCl above; Breitinger et al. J Organomet Chem 256 217 1983,max Slotta et al. J Prakt Chem 120 249 1929, Waugh et al. J Phys Chem 59 395 1955, Beilstein 16 IV 1729.]
塩化メチル水銀 上流と下流の製品情報
原材料
準備製品