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MS37452

化学構造式
423748-02-1
CAS番号.
423748-02-1
化学名:
别名:
英語名:
MS37452
英語别名:
MS37452;1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine;1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone;1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone;Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-;MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452
CBNumber:
CB43060612
化学式:
C22H26N2O5
分子量:
398.45224
MOL File:
423748-02-1.mol

MS37452 物理性質

沸点 :
628.8±55.0 °C(Predicted)
比重(密度) :
1.209±0.06 g/cm3(Predicted)
貯蔵温度 :
-20°C
溶解性:
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
酸解離定数(Pka):
-1.31±0.70(Predicted)
外見 :
粉
色:
白からベージュ

安全性情報

MS37452 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan SML1405 ≥98% (HPLC)
MS37452 ≥98% (HPLC)		 423748-02-1 5mg ￥20600 2024-03-01 購入
Sigma-Aldrich Japan SML1405 ≥98% (HPLC)
MS37452 ≥98% (HPLC)		 423748-02-1 25mg ￥81800 2024-03-01 購入

MS37452 化学特性,用途語,生産方法

説明

Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression. MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 μM). At 250 μM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.

使用

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 and has been shown to derepress transcription of the polycomb repressive complex target gene.

Biochem/physiol Actions

MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. MS37452 inhibits CBX7 binding to INK4/ARF gene locus, and induces decline of p14/ARF and p16/INK4a in human PC3 cells.

MS37452 上流と下流の製品情報

原材料

準備製品

MS37452 生産企業

Global( 45)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4121 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9709 58
Shanghai Changyan Chem & Tech Co., Ltd. 021-021-20242659 18930833303
 order@changyanchem.com China 5008 55
Beijing OKA biological technology co., LTD 010-62971590 18548936886
 3462612863@qq.com China 6912 58
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9414 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11289 58
Absin Bioscience Inc. 021-38015121 15000105423
 chenjw@absin.cn China 24734 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8141 58
  • 423748-02-1
  • MS37452
  • 1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine
  • Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-
  • 1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone
  • 1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone
  • MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452
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