MS37452
- CAS No.
- 423748-02-1
- Chemical Name:
- MS37452
- Synonyms
- MS37452;1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine;1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone;1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone;Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-;1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethan-1-one;MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452
- CBNumber:
- CB43060612
- Molecular Formula:
- C22H26N2O5
- Molecular Weight:
- 398.45224
- MDL Number:
- MFCD03134667
- MOL File:
- 423748-02-1.mol
- MSDS File:
- SDS
MS37452 price More Price(12)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1405 | MS37452 ≥98% (HPLC) | 423748-02-1 | 5MG | $142 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1405 | MS37452 ≥98% (HPLC) | 423748-02-1 | 25MG | $451 | 2023-06-20 | Buy |
Cayman Chemical | 17533 | MS37452 ≥98% | 423748-02-1 | 1mg | $38 | 2024-03-01 | Buy |
Cayman Chemical | 17533 | MS37452 ≥98% | 423748-02-1 | 5mg | $111 | 2024-03-01 | Buy |
Cayman Chemical | 17533 | MS37452 ≥98% | 423748-02-1 | 10mg | $184 | 2024-03-01 | Buy |
MS37452 Chemical Properties,Uses,Production
Description
Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression. MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 μM). At 250 μM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.
Uses
MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 and has been shown to derepress transcription of the polycomb repressive complex target gene.
Biochem/physiol Actions
MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. MS37452 inhibits CBX7 binding to INK4/ARF gene locus, and induces decline of p14/ARF and p16/INK4a in human PC3 cells.
in vitro
in a previous study, the crystal structures revealed the binding modes of ms37452 and its close analogs that competed against h3k27me3 binding via interactions with key residues in the methyl-lysine binding pocket of cbx7chd. it was further found that ms37452 as the lead compound was able to derepress the transcription of polycomb repressive complex target gene p16/cdkn2a through displacing cbx7 binding to the ink4a/arf locus in prostate cancer cells. these findings showed that ms37452 and its close analogs had the potential to be developed into high-potency chemical modulators targeting cbx7 functions in gene transcription in various disease pathways [1].
References
[1] ren, c. ,morohashi, k.,plotnikov, a.n., et al. small-molecule modulators of methyl-lysine binding for the cbx7 chromodomain. chemistry & biology 22, 161-168 (2015).
MS37452 Preparation Products And Raw materials
Raw materials
Preparation Products
MS37452 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4314 | 55 | |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
Shanghai Changyan Chem & Tech Co., Ltd. | 021-021-20242659 18930833303 | order@changyanchem.com | China | 5011 | 55 |
Beijing OKA biological technology co., LTD | 010-010-010-62971590 18548936886 | jack@oka-vip.com | China | 6897 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |