N-(2-ピリジル)-N-(2-チエニルメチル)-N',N'-ジメチルエチレンジアミン 化学特性,用途語,生産方法
化学的特性
colourless liquid
使用
Methapyrilene is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.
定義
ChEBI: A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
世界保健機関（WHO）
Methapyrilene, an antihistamine with moderate sedative activity,
was introduced in 1947 for the treatment of various allergic conditions and was
subsequently incorporated in many over-the-counter sleeping aids. In the early
1970s it was identified as a carcinogen in rats and, although there was no direct
evidence that it constitutes a health hazard to man, it was withdrawn in many
countries.
(Reference: (WHODI) WHO Drug Information, 2, 4, 1979)
一般的な説明
Clear colorless liquid.
反応プロフィール
An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
健康ハザード
ACUTE/CHRONIC HAZARDS: METHAPYRILENE is highly toxic by ingestion.
火災危険
Flash point data for METHAPYRILENE are not available, but METHAPYRILENE is probably combustible.
代謝経路
When methaphenilene is
incubated with rat liver microsomes, it is metabolized via N-oxide formation and
N-dealkylation which includes removal of the
dimethylamino moiety, the thiophenylmethyl moiety of
methaphenilene, and the benzyl moiety of
pyribenzamine.
N-(2-ピリジル)-N-(2-チエニルメチル)-N',N'-ジメチルエチレンジアミン 上流と下流の製品情報
原材料
準備製品