메타피릴렌
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메타피릴렌 속성
- 녹는점
- 25°C
- 끓는 점
- bp0.45 125-135°; bp3 173-175°
- 밀도
- 1.1388 (rough estimate)
- 굴절률
- nD25 1.5842 (also reported as 1.5835)
- 저장 조건
- Refrigerator, under inert atmosphere
- 용해도
- DMSO(적게), 메탄올(약간)에 용해됨
- 물리적 상태
- 기름
- 산도 계수 (pKa)
- pKa 3.02 ± 0.05;8.24± 0.11(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
- 색상
- 무색~연황색
- 수용성
- 601.2mg/L(30℃)
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 유엔번호(UN No.) | 1851 | ||
|---|---|---|---|
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| 유해 물질 데이터 | 91-80-5(Hazardous Substances Data) | ||
| 독성 | LD50 in mice, guinea pigs (mg/kg): 182.2 ±12.8, 374.9 ±34.5 orally; in mice (mg/kg): 19.85 ±0.69 i.v. (Lee) |
| 그림문자(GHS): |
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| 신호 어: | Danger | ||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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메타피릴렌 C화학적 특성, 용도, 생산
화학적 성질
colourless liquid용도
Methapyrilene is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.정의
ChEBI: A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.World Health Organization (WHO)
Methapyrilene, an antihistamine with moderate sedative activity, was introduced in 1947 for the treatment of various allergic conditions and was subsequently incorporated in many over-the-counter sleeping aids. In the early 1970s it was identified as a carcinogen in rats and, although there was no direct evidence that it constitutes a health hazard to man, it was withdrawn in many countries. (Reference: (WHODI) WHO Drug Information, 2, 4, 1979)일반 설명
Clear colorless liquid.반응 프로필
An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.건강위험
ACUTE/CHRONIC HAZARDS: METHAPYRILENE is highly toxic by ingestion.화재위험
Flash point data for METHAPYRILENE are not available, but METHAPYRILENE is probably combustible.신진 대사 경로
When methaphenilene is incubated with rat liver microsomes, it is metabolized via N-oxide formation and N-dealkylation which includes removal of the dimethylamino moiety, the thiophenylmethyl moiety of methaphenilene, and the benzyl moiety of pyribenzamine.메타피릴렌 준비 용품 및 원자재
원자재
염산
나트륨아미드
2-아미노피리딘
N-(2-thienylmethyl)pyridin-2-amine
2-브로모피리딘
2-(Chloromethyl)thiophene
2-Chloroethyldimethylamine
준비 용품
메타피릴렌 공급 업체
글로벌( 15)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 9116 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 |
info@tsbiochem.com | China | 8073 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 |
sales@chem-strong.com | China | 17982 | 56 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 |
sales@rrkchem.com | China | 55827 | 58 |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 |
shanpel@anpel.com.cn | China | 9614 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 |
sales@tcisct.com | China | 31163 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 |
1027@dideu.com | China | 9941 | 58 |