[N,N,N',N'-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン]

[N,N,N',N'-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン] 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

[N,N,N',N'-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン] 化学特性,用途語,生産方法

Originator

Jenotone,Coopers

Manufacturing Process

Phenothiazine (20 g) is heated under reflux for 1 hour with sodium amide (5 g) in xylene (80 ml). A solution of 1,3-bis(dimethylamino)-2-chloropropane (27 g) (prepared by a method analogous to that described in Ingold and Rothstein J.C.S. 1931, 1676) in xylene (30 ml) is then added over 2 hours. Heating is continued for a further 1 hour and then the mixture is taken up in water (270 ml) and hydrochloric acid (d=1.19; 20 ml). The decanted acid layer is treated with caustic soda (d 1.33; 25 ml) and the base is extracted with ether (2 x 50 ml) which is then dried over potassium carbonate. On distillation there is obtained at 218-220°C/0.6 mm Hg a mixture (20 g) containing a major proportion of 10-[2,3-bis(dimethylamino)-1- propyl]phenothiazine and a minor proportion of 10-[1,3-bis(dimethylamino)-1- propyl]phenothiazine.
A mixture of bases (11 g) obtained is dissolved in isopropanol (25 ml). Ether (25 ml) containing dry hydrogen chloride (2 g) is added, the mixture is left to crystallise overnight in a refrigerator and the product is filtered off, washed and dried. There is thus obtained a salt (2.5 g), M.P. 244°C, which is 10-[1,3- bis(dimethylamino)-1-propyl]phenothiazine hydrochloride.
On evaporation of the mother liquors from the above hydrochloride a residue is obtained from which is isolated its isomer, 10-[2,3-bis(dimethylamino)-1- propyl]phenothiazine, the base crystallising from ethanol and melting at 58°C. The structure of these two isomers has been confirmed by comparison of their infra-red adsorption spectra with those of related products of known structure.
In practice it is usually used as fumarate.

Therapeutic Function

Spasmolytic

[N,N,N',N'-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン] 上流と下流の製品情報

原材料

準備製品

[N,N,N',N'-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン] 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3218	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29016	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58

58-37-7([N,N,N',N'-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン])キーワード:

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• 58-37-7
• Proquamezine
• N,N,N',N'-Tetramethyl-3-(10H-phenothiazin-10-yl)-1,2-propanediamine
• [1-(dimethylaminomethyl)-2-phenothiazin-10-yl-ethyl]-dimethyl-amine
• 1-N,1-N,2-N,2-N-tetramethyl-3-phenothiazin-10-ylpropane-1,2-diamine
• N1,N1,N2,N2-tetramethyl-3-phenothiazin-10-yl-propane-1,2-diamine
• aminopromazine
• 1,2-Propanediamine, N1,N1,N2,N2-tetramethyl-3-(10H-phenothiazin-10-yl)-
• Aminopromazine USP/EP/BP
• Tetrameprozine
• プロクアメジン
• [N,N,N',N'-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン]
• N,N,N',N'-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン
• アミノプロマジン
• N,N,N′,N′-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン
• [1-(ジメチルアミノ)-3-(10H-フェノチアジン-10-イル)プロパン-2-イル]ジメチルアミン
• [N,N,N′,N′-テトラメチル-3-(10H-フェノチアジン-10-イル)-1,2-プロパンジアミン]