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Aminopromazine

Aminopromazine Structure
Aminopromazine structure
CAS No.
58-37-7
Chemical Name:
Aminopromazine
Synonyms
Proquamezine;aminopromazine;Tetrameprozine;Aminopromazine USP/EP/BP;N1,N1,N2,N2-tetramethyl-3-phenothiazin-10-yl-propane-1,2-diamine;1-N,1-N,2-N,2-N-tetramethyl-3-phenothiazin-10-ylpropane-1,2-diamine;[1-(dimethylaminomethyl)-2-phenothiazin-10-yl-ethyl]-dimethyl-amine;N,N,N',N'-Tetramethyl-3-(10H-phenothiazin-10-yl)-1,2-propanediamine;1,2-Propanediamine, N1,N1,N2,N2-tetramethyl-3-(10H-phenothiazin-10-yl)-
CBNumber:
CB4936691
Molecular Formula:
C19H25N3S
Molecular Weight:
327.49
MDL Number:
MOL File:
58-37-7.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:40
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Aminopromazine Properties

FDA UNII S9SDD93U5U
NIST Chemistry Reference 1,2-Propanediamine, n,n,n',n'-tetramethyl-3-(10h-phenothiazin-10-yl)-(58-37-7)

Aminopromazine Chemical Properties,Uses,Production

Originator

Jenotone,Coopers

Definition

ChEBI: Aminopromazine is a member of phenothiazines.

Manufacturing Process

Phenothiazine (20 g) is heated under reflux for 1 hour with sodium amide (5 g) in xylene (80 ml). A solution of 1,3-bis(dimethylamino)-2-chloropropane (27 g) (prepared by a method analogous to that described in Ingold and Rothstein J.C.S. 1931, 1676) in xylene (30 ml) is then added over 2 hours. Heating is continued for a further 1 hour and then the mixture is taken up in water (270 ml) and hydrochloric acid (d=1.19; 20 ml). The decanted acid layer is treated with caustic soda (d 1.33; 25 ml) and the base is extracted with ether (2 x 50 ml) which is then dried over potassium carbonate. On distillation there is obtained at 218-220°C/0.6 mm Hg a mixture (20 g) containing a major proportion of 10-[2,3-bis(dimethylamino)-1- propyl]phenothiazine and a minor proportion of 10-[1,3-bis(dimethylamino)-1- propyl]phenothiazine.
A mixture of bases (11 g) obtained is dissolved in isopropanol (25 ml). Ether (25 ml) containing dry hydrogen chloride (2 g) is added, the mixture is left to crystallise overnight in a refrigerator and the product is filtered off, washed and dried. There is thus obtained a salt (2.5 g), M.P. 244°C, which is 10-[1,3- bis(dimethylamino)-1-propyl]phenothiazine hydrochloride.
On evaporation of the mother liquors from the above hydrochloride a residue is obtained from which is isolated its isomer, 10-[2,3-bis(dimethylamino)-1- propyl]phenothiazine, the base crystallising from ethanol and melting at 58°C. The structure of these two isomers has been confirmed by comparison of their infra-red adsorption spectra with those of related products of known structure.
In practice it is usually used as fumarate.

Therapeutic Function

Spasmolytic

Aminopromazine Preparation Products And Raw materials

Raw materials

Sodium amide Phenothiazine

Preparation Products

Aminopromazine Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Shaanxi Dideu Medichem Co. Ltd 		18192627656 1012@dideu.com China 3218 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29016 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Shaanxi Didu New Materials Co. Ltd 		+86-89586680 +86-13289823923 1026@dideu.com China 9116 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58
Shaanxi Didu New Materials Co. Ltd 		58
Energy Chemical 58

View Lastest Price from Aminopromazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Aminopromazine USP/EP/BP pictures 2021-05-29 Aminopromazine USP/EP/BP
58-37-7
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Aminopromazine pictures 2020-04-25 Aminopromazine
58-37-7
 US $0.01-1.00 / KG 1KG 99% 50 tons Shaanxi Dideu Medichem Co. Ltd

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Aminopromazine

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Proquamezine N,N,N',N'-Tetramethyl-3-(10H-phenothiazin-10-yl)-1,2-propanediamine [1-(dimethylaminomethyl)-2-phenothiazin-10-yl-ethyl]-dimethyl-amine 1-N,1-N,2-N,2-N-tetramethyl-3-phenothiazin-10-ylpropane-1,2-diamine N1,N1,N2,N2-tetramethyl-3-phenothiazin-10-yl-propane-1,2-diamine aminopromazine 1,2-Propanediamine, N1,N1,N2,N2-tetramethyl-3-(10H-phenothiazin-10-yl)- Aminopromazine USP/EP/BP Tetrameprozine 58-37-7 C19H25N3S