5-Nonyloxytryptamine oxalate 化学特性,用途語,生産方法
説明
Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT
1Dβ with an EC
50 value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT
1Dβ receptor. It is selective for 5-HT
1Dβ over 5-HT
1A for its adenylate cyclase activity, with an EC
50 greater than 1 μM for 5-HT
1A. It binds to 5-HT
1Dβ, 5-HT
1A, 5-HT
1B, 5-HT
2A, and 5-HT
2C receptors
in vitro (K
is = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization.
使用
5-Nonyloxytryptamine Oxalate is a selective 5-HT1B agonist.
Biochem/physiol Actions
Nonyloxytryptamine (5-nonyloxytryptamine) is a potent and selective 5-HT1B receptor agonist. Nonyloxytryptamine is a polysialic acid (PSA) mimick that triggers PSA-mediated functions. Nonyloxytryptamine enhances neurite outgrowth of cultured primary neurons, protects neurons from oxidative stress, enhanced Schwann cell proliferation, reduces migration of astrocytes and enhances myelination in vitro.
5-Nonyloxytryptamine oxalate 上流と下流の製品情報
原材料
準備製品