5-Nonyloxytryptamine oxalate

Description

Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT_1Dβ with an EC₅₀ value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT_1Dβ receptor. It is selective for 5-HT_1Dβ over 5-HT_1A for its adenylate cyclase activity, with an EC₅₀ greater than 1 μM for 5-HT_1A. It binds to 5-HT_1Dβ, 5-HT_1A, 5-HT_1B, 5-HT_2A, and 5-HT_2C receptors in vitro (K_is = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization.

Uses

5-Nonyloxytryptamine Oxalate is a selective 5-HT1B agonist.

Definition

ChEBI: 5-nonyloxytryptamine oxalate is an oxalate salt obtained by reaction of 5-nonyloxytryptamine with one equivalent of oxalic acid. 5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). It has a role as a serotonergic agonist. It contains a 5-nonyloxytryptaminium(1+).

Biochem/physiol Actions

Nonyloxytryptamine (5-nonyloxytryptamine) is a potent and selective 5-HT1B receptor agonist. Nonyloxytryptamine is a polysialic acid (PSA) mimick that triggers PSA-mediated functions. Nonyloxytryptamine enhances neurite outgrowth of cultured primary neurons, protects neurons from oxidative stress, enhanced Schwann cell proliferation, reduces migration of astrocytes and enhances myelination in vitro.

Raw materials

Preparation Products