5-メトキシ-2-メチル-1-(1-オキソ-3-フェニル-2-プロペニル)-1H-インドール-3-酢酸
5-メトキシ-2-メチル-1-(1-オキソ-3-フェニル-2-プロペニル)-1H-インドール-3-酢酸 物理性質
- 融点 :
- 170-172°; mp 164-165°
- 沸点 :
- 483.57°C (rough estimate)
- 比重(密度) :
- 1.2520 (rough estimate)
- 屈折率 :
- 1.5614 (estimate)
- 酸解離定数(Pka):
- 4.00±0.30(Predicted)
- 水溶解度 :
- <1mg/L(25℃)
安全性情報
| 毒性 |
LD50 in mice, rats (mg/kg): 360, 590 i.p.; 750, 1020 orally (Komatsu) |
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5-メトキシ-2-メチル-1-(1-オキソ-3-フェニル-2-プロペニル)-1H-インドール-3-酢酸 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
5-メトキシ-2-メチル-1-(1-オキソ-3-フェニル-2-プロペニル)-1H-インドール-3-酢酸 化学特性,用途語,生産方法
Originator
Cindomet,Chiesi
Manufacturing Process
6.0 g of cinnamoyl chloride was dropwise added to a mixture of 8.7 g of pmethoxyphenylhydrazine hydrochloride, 10.1 g of triethylamine and 200 ml of
toluene under cooling at -5° to 0°C. The reaction mixture was stirred at 20°-
25°C for 1 h. The separated precipitates were filtered off and dry gaseous
hydrogen chloride was introduced into the filtrate. As a result a large amount
of crystals of N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine hydrochloride
were produced. These crystals were collected by filtration and washed with 20
ml of ether and dried to yield N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine
hydrochloride of melting point 183°-185°C.
A mixture of N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine hydrochloride and
acetonylmalonic acid was heated in acetic acid at heating with stirring.
Thereafter, the reaction mixture was allowed to cool, and was poured into cold
water, and then crystals were produced. They were collected by filtration, and
dried to give crude product. The recrystallization from acetone-water gave fine
white needle crystals of 1-cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid,
melting point 164°-165°C.
Therapeutic Function
Antiinflammatory
5-メトキシ-2-メチル-1-(1-オキソ-3-フェニル-2-プロペニル)-1H-インドール-3-酢酸 上流と下流の製品情報
原材料
準備製品
5-メトキシ-2-メチル-1-(1-オキソ-3-フェニル-2-プロペニル)-1H-インドール-3-酢酸 生産企業
Global( 8)Suppliers
20168-99-4(5-メトキシ-2-メチル-1-(1-オキソ-3-フェニル-2-プロペニル)-1H-インドール-3-酢酸)キーワード:
- 20168-99-4
- cinmetacin
- Indolacin
- cinmethacin
- 1-(1-Oxo-3-phenyl-2-propenyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
- 5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid
- Cindomet
- 1H-Indole-3-acetic acid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
- cinmetacin USP/EP/BP
- 1-(1-オキソ-3-フェニル-2-プロペニル)-5-メトキシ-2-メチル-1H-インドール-3-酢酸
- 5-メトキシ-2-メチル-1-(1-オキソ-3-フェニル-2-プロペニル)-1H-インドール-3-酢酸
- シンドメット
- シンメタシン
- インドラシン
- 2-[5-メトキシ-2-メチル-1-(3-フェニルプロパ-2-エノイル)-1H-インドール-3-イル]酢酸