コレセベラム塩酸塩
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
コレセベラム塩酸塩 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0103-2485 |
コレセベラム塩酸塩
Colesevelam Hydrochloride |
182815-44-7 |
200mg |
￥12600 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0103-2485 |
コレセベラム塩酸塩
Colesevelam Hydrochloride |
182815-44-7 |
1g |
￥43000 |
2020-09-21 |
購入 |
コレセベラム塩酸塩 化学特性,用途語,生産方法
外観
白色～うすい黄色、結晶性粉末～粉末
用途
胆汁酸補足剤です。胆汁酸と
結合し、胆汁酸の血中への再吸収を阻害しま
す。肝臓が胆汁酸を産生するために血中コレ
ステロールを取り込むことで、コレステロー
ル低下作用を示します。
説明
Colesevelam hydrochloride was launched as Welchol (formerly known as Cholestagel)
in the US for the reduction of elevated levels of serum LDL cholesterol and accordingly,
the decrease of the risk of vascular disease in patients with primary hypercholesterolemia.
This orally administered cationic hydrogel is a non-absorbable, water-insoluble polymer of
an hexanaminium chloride with N-(2-propenyl) decanamine, 2-propen-1-amine
hydrochloride and chloromethyloxirane. It acts as a powerful bile acid sequestering agent,
this binding and blockage of bile acids having the end result of compelling the removal of
LDL cholesterol from the blood stream into the liver. In animals fed with a cholesterol-rich
diet for several weeks, colesevelam demonstrated a good maintenance of low serum
cholesterol levels, this activity being significantly greater when compared with
cholestyramine. In several placebo-controlled studies, this agent decreased total
cholesterol levels by 6 to 10% and LDL cholesterol levels by 9 to 20%. Combination
therapy with the co-administration of a HMG-CoA reductase inhibitor (or statin) and
colesevelam produced an additional reduction of 8-16% in LDL-cholesterol levels above
that obtained with the statin alone. Due to its unique water-absorbing hydrogel formulation,
this polymer is not absorbed at all from the GI tract, and thus, it is said to have a lower rate
of side-effects (as the constipating effect) than the previously marketed bile acid
sequestrants. Colesevelam hydrochloride may be used as a monotherapy or as a dual
therapy with statins.
使用
Colesevelam Hydrochloride is used to reduce elevated low-density lipoprotein (LDL) cholesterol in patients with primary hyperlipidemia as well as to improve glycemic control in patients with type 2 diabetes.
定義
ChEBI: The hydrochloride of colesevelam. It is used as an orally administered bile acid sequestrant to reduce the amount of cholesterol and certain fatty substances in the blood.
一般的な説明
Colesevelam (Welchol) is one of themore recent additions to the class of bile acid-sequesteringagents. Its structure is rather novel, and at first glance, it appearsto look like the previous examples of cholestyramineand colestipol. It does not possess the chloride ions, however,and, strictly speaking, is not an anion-exchange resin.This compound has good selectivity for both the trihydroxyand dihydroxy bile acids. The selectivity for these hydroxylatedderivatives lends some insight into the reduced side effectscolesevelam possesses, compared with cholestyramineand colestipol. Unlike the older agents, colesevelam doesnot have a high incidence of causing constipation. This resultsfrom the compound’s ability to “pick up” water as a resultof its affinity for hydroxyl system (i.e., hydrogen bondingwith either the bile acid or water). In turn, this yieldssofter, gel-like materials that are easier to excrete.
コレセベラム塩酸塩 上流と下流の製品情報
原材料
準備製品
コレセベラム塩酸塩 生産企業
Global( 103)Suppliers
182815-44-7(コレセベラム塩酸塩)キーワード:
- 182815-44-7
- Colesevelam and Colesevelam Hydrochloride
- colesevelam hcl API
- Colesevelam
- 2-Propen-1-amine polymer with (chloromethyl)oxirane, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride hydrochloride
- Colesevelam USP/EP/BP
- Colesevelam USP
- Colesevelam HydrochlorideQ: What is
Colesevelam Hydrochloride Q: What is the CAS Number of
Colesevelam Hydrochloride Q: What is the storage condition of
Colesevelam Hydrochloride Q: What are the applications of
Colesevelam Hydrochloride
- Colesevelam hydrochloride
- COLESEVALAM
- Colesevelam HCL
- Cholestagel, Colesevelam hydrochloride
- Colesevelam,inhibit,Colesevelam Hydrochloride,Inhibitor
- Colesevelam HCL INN
- Colleveran hydrochloride
- コレセベラム塩酸塩