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Colesevelam

Colesevelam 구조식 이미지
카스 번호:
182815-44-7
상품명:
Colesevelam
동의어(영문):
COLESEVALAM;Colesevelam;Colesevelam HCL;colesevelam hcl API;Colesevelam hydrochloride;Colesevelam and Colesevelam Hydrochloride;2-Propen-1-amine polymer with (chloromethyl)oxirane, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride hydrochloride
CBNumber:
CB7946983
분자식:
C31H67Cl3N4O
포뮬러 무게:
618.24888
MOL 파일:
182815-44-7.mol

Colesevelam 속성

안전

Colesevelam C화학적 특성, 용도, 생산

개요

Colesevelam hydrochloride was launched as Welchol (formerly known as Cholestagel) in the US for the reduction of elevated levels of serum LDL cholesterol and accordingly, the decrease of the risk of vascular disease in patients with primary hypercholesterolemia. This orally administered cationic hydrogel is a non-absorbable, water-insoluble polymer of an hexanaminium chloride with N-(2-propenyl) decanamine, 2-propen-1-amine hydrochloride and chloromethyloxirane. It acts as a powerful bile acid sequestering agent, this binding and blockage of bile acids having the end result of compelling the removal of LDL cholesterol from the blood stream into the liver. In animals fed with a cholesterol-rich diet for several weeks, colesevelam demonstrated a good maintenance of low serum cholesterol levels, this activity being significantly greater when compared with cholestyramine. In several placebo-controlled studies, this agent decreased total cholesterol levels by 6 to 10% and LDL cholesterol levels by 9 to 20%. Combination therapy with the co-administration of a HMG-CoA reductase inhibitor (or statin) and colesevelam produced an additional reduction of 8-16% in LDL-cholesterol levels above that obtained with the statin alone. Due to its unique water-absorbing hydrogel formulation, this polymer is not absorbed at all from the GI tract, and thus, it is said to have a lower rate of side-effects (as the constipating effect) than the previously marketed bile acid sequestrants. Colesevelam hydrochloride may be used as a monotherapy or as a dual therapy with statins.

Originator

GelTex (US)

용도

antibacterial

정의

ChEBI: The hydrochloride of colesevelam. It is used as an orally administered bile acid sequestrant to reduce the amount of cholesterol and certain fatty substances in the blood.

상표명

Welchol (Sankyo).

일반 설명

Colesevelam (Welchol) is one of themore recent additions to the class of bile acid-sequesteringagents. Its structure is rather novel, and at first glance, it appearsto look like the previous examples of cholestyramineand colestipol. It does not possess the chloride ions, however,and, strictly speaking, is not an anion-exchange resin.This compound has good selectivity for both the trihydroxyand dihydroxy bile acids. The selectivity for these hydroxylatedderivatives lends some insight into the reduced side effectscolesevelam possesses, compared with cholestyramineand colestipol. Unlike the older agents, colesevelam doesnot have a high incidence of causing constipation. This resultsfrom the compound’s ability to “pick up” water as a resultof its affinity for hydroxyl system (i.e., hydrogen bondingwith either the bile acid or water). In turn, this yieldssofter, gel-like materials that are easier to excrete.

Colesevelam 준비 용품 및 원자재

원자재

준비 용품


Colesevelam 공급 업체

글로벌( 38)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12341 58
China Nobel Chem Co., Limited +86(0)21 60484900
+86(0)21 60484900 sales@nobelchem.com China 767 50
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
025-57019371 sales@sunlidabio.com China 3818 55
Zouping Mingxing Chemical Co.,Ltd. 13605431940
0086-0543-2240079 zpmxchemical@126.com China 1142 62
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
021-34692979 info@tsbiochem.com China 8074 58
Tianjin Olefin Pharmaceutical Co., Ltd. 18202662021
022-25541300 2211422945@qq.com China 351 56
Hainan Manfangyuan Pharmaceutical Chemical Co., Ltd. +86 (898) 6651-8050
+86 (898) 6677-5768 mfy001@hnmfy.com China 85 60

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