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2-ジエチルアミノエタノール

2-ジエチルアミノエタノール 化学構造式
100-37-8
CAS番号.
100-37-8
化学名:
2-ジエチルアミノエタノール
别名:
2-ジエチルアミノエタノール;2-ヒドロキシエチルジエチルアミン;デヒダサル;2-(ジエチルアミノ)エタノール;2-(N,N-ジエチルアミノ)エタノール;デハイダサル;ジエチルエタノールアミン;N,N-ジエチルエタノールアミン;N,N-ジエチルエタノルアミン;N,Nジエチルエタノルアミン;(2-ヒドロキシエチル)ジエチルアミン;2‐(ジエチルアミノ)エタノール;2‐ジエチルアミノエタノール;2 - ジエチルアミノエタノール;2-(ジエチルアミノ)エタノ-ル
英語化学名:
Diethylaminoethanol
英語别名:
DEEA;DEAE;100-37-8;Dehydasal;Rotec A.O.;Pennad 150;Perdilaton;-Diethylamino;Loramine AMB 13;Dietyleneglycol
CBNumber:
CB5752557
化学式:
C6H15NO
分子量:
117.19
MOL File:
100-37-8.mol

2-ジエチルアミノエタノール 物理性質

融点 :
-70 °C
沸点 :
161 °C (lit.)
比重(密度) :
0.884 g/mL at 25 °C (lit.)
蒸気密度:
4.04 (vs air)
蒸気圧:
1 mm Hg ( 20 °C)
屈折率 :
n20/D 1.441(lit.)
闪点 :
120 °F
貯蔵温度 :
Store below +30°C.
溶解性:
soluble
外見 :
Crystalline Powder
酸解離定数(Pka):
14.74±0.10(Predicted)
色:
White to pale yellow
PH:
11.5 (100g/l, H2O, 20℃)
酸塩基指示薬変色域(pH):
10
爆発限界(explosive limit):
0.7%(V)
水溶解度 :
soluble
凝固点 :
-70℃
Merck :
14,3112
BRN :
741863
暴露限界値:
NIOSH REL: TWA 10 ppm (50 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 2 ppm (adopted).
安定性::
Stable. Flammable. Incompatible with strong oxidizing agents, acids. Moisture sensitive. Hygroscopic.
InChIKey:
BFSVOASYOCHEOV-UHFFFAOYSA-N
CAS データベース:
100-37-8(CAS DataBase Reference)
NISTの化学物質情報:
Ethanol, 2-(diethylamino)-(100-37-8)
EPAの化学物質情報:
Diethylaminoethanol (100-37-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  C
Rフレーズ  10-20/21/22-34
Sフレーズ  25-26-36/37/39-45
RIDADR  UN 2686 8/PG 2
WGK Germany  1
RTECS 番号 KK5075000
自然発火温度 270 °C
TSCA  Yes
国連危険物分類  8
容器等級  II
HSコード  29221985
有毒物質データの 100-37-8(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 1300 mg/kg LD50 dermal Rabbit 1109 mg/kg
消防法 危-4-2-III
化審法 (2)-297, (2)-353
安衛法 57,57-2
PRTR法 第一種指定化学物質
毒劇物取締法 劇物
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H226 引火性の液体および蒸気 引火性液体 3 警告
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P262 眼、皮膚、衣類につけないこと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P310 ただちに医師に連絡すること。
P370+P378 火災の場合:消火に...を使用すること。

2-ジエチルアミノエタノール 価格 もっと(12)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0104-1854 N,N-ジエチルエタノールアミン 97.0+% (Capillary GC)
N,N-Diethylethanolamine 97.0+% (Capillary GC)
100-37-8 25mL ¥2100 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01W0104-1854 N,N-ジエチルエタノールアミン 97.0+% (Capillary GC)
N,N-Diethylethanolamine 97.0+% (Capillary GC)
100-37-8 500mL ¥2700 2021-03-23 購入
東京化成工業 D0465 2-ジエチルアミノエタノール >99.0%(GC)(T)
2-Diethylaminoethanol >99.0%(GC)(T)
100-37-8 25mL ¥1600 2021-03-23 購入
東京化成工業 D0465 2-ジエチルアミノエタノール >99.0%(GC)(T)
2-Diethylaminoethanol >99.0%(GC)(T)
100-37-8 500mL ¥2400 2021-03-23 購入
関東化学株式会社(KANTO) 10210-30 2‐ジエチルアミノエタノール >98.0%(GC)
2‐Diethylaminoethanol >98.0%(GC)
100-37-8 25mL ¥1700 2021-03-23 購入

2-ジエチルアミノエタノール 化学特性,用途語,生産方法

外観

無色~わずかにうすい黄色, 澄明の液体

定義

本品は、次の化学式で表されるアミン誘導体である。

溶解性

水に混和, エタノールに可溶。水、エタノール及びアセトンに極めて溶けやすい。

用途

抗ヒスタミン剤、抗マラリヤ剤

用途

均染剤(繊維用)及び????化剤(紙加工用)の合成原料、医薬品原料、乳化剤(????添加用)、防錆剤。

化粧品の成分用途

緩衝剤

化学的特性

colourless liquid

物理的性質

Colorless, hygroscopic liquid with a nauseating, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 50 μg/m3 (11 ppbv) and 190 μg/m3 (40 ppbv), respectively (Hellman and Small, 1974).

使用

Water-soluble salts; textile softeners; antirust formulations; fatty acid derivatives; pharmaceuticals; curing agent for resins; emulsifying agents in acid media; organic synthesis.

使用

Anticorrosive agent; chemical intermediate for the production of emulsifiers, detergents, solubilizers, cosmetics, drugs, and textile finishing agents

使用

Diethylethanolamine?can be used as a precursor chemical to?procaine. It is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen. it is used for the synthesis of drugs in the pharmaceutical industry and as a catalyst for the synthesis of polymers in the chemical industry. It is also used as a pH stabilizer.

定義

ChEBI: A member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.

調製方法

2-Diethylaminoethanol (DEAE) is a tertiary amine produced by reaction of ethylene oxide or ethylene chlorhydrin and diethylamine (RTECS 1988). Itokazu (1987) has modified this process for manufacture of DEAE without eventual discoloration. Production in this country exceeds 2866 pounds per year (HSDB 1988).

一般的な説明

A colorless liquid. Flash point 103-140°F. Less dense than water . Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Causes burns to the skin, eyes and mucous membranes.

空気と水の反応

Flammable. Soluble in water. Diethylaminoethanol is sensitive to moisture. Slowly hydrolyzes.

反応プロフィール

Diethylaminoethanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Diethylaminoethanol can react with strong oxidizers and acids.

健康ハザード

INHALATION: Irritation of mucous membranes. EYES: Corrosive, causes intense pain. SKIN: Severe irritation. May cause allergic skin reaction. INGESTION: Gastrointestinal irritation.

健康ハザード

There is a lack of data regarding human toxicity of DEAE. There have been reported cases of skin and eye irritation, as well as dizziness and headache from workers in buildings which use DEAE as a steam additive (HSDB 1988). In this case, it is thought that contact through condensation and accumulation on surfaces is the cause of irritation as the sampling of air in these buildings yielded levels far below that recommended by NIOSH (1980) of a threshold limit value (TLV) time weighted average of 10 p.p.m. on the skin, or approximately 50 mg/m3 (ACGIH 1980). On the basis of data from Cornish (1965) and ACGIH (1980), the TLV is also below the level which will cause irritation directly to the eye. The greatest industrial hazard however, is thought to be to the eyes from contact with the fluid, which is comparable in severity to ammonium hydroxide as an eye irritant (ACGIH 1980).
DEAE is permitted by the U.S. Food and Drug Administration for some applications as a food additive. Applications include protective coatings for fresh fruits and vegetables, and as an additive in steam which directly contacts food products (excluding milk products). The National Research Council Committee on Toxicology (NRC 1983) has concluded that data on long-term, low-level airborne exposures of animals to DEAE for extrapolation to human health risks are severely lacking. This, combined with the lack of data concerning the concentrations of DEAE in humidified buildings did not allow sufficient information to set guidelines for long-term exposures or estimate the health risks from such exposures. The NRC was able to make some general recommendations based on the assumption that the nitrosation reactions (below) may occur, and that the amine should be considered as hazardous as the nitroso compound formed from it. The recommendations are:
1. The Navy should use boiler additives that are least likely to be nitrosated and that do not have other adverse effects on health that would preclude their use.
2. DEAE and morpholine should not be used in concert in a steam generating system when human exposure to the steam may occur.
3. When amines are used in steam generating systems, the air in rooms where the steam is used and the steam condensate is found should be monitored for the presence of amines and nitrosamines.
4. If DEAE, morpholine, or other nitrosatable volatile amines are used in steam generating systems where humans may be exposed to the steam, the amounts of amines added should be reduced as much as possible.
5. When amines are added to a steam generating system, they should be added continuously in small amounts, rather than in one large daily dose.

工業用途

DEAE is used in the pharmaceutical industry for the manufacture of the local anesthetics procaine and chloroquine; and in the chemical industry for the manufacture of water-soluble salts, fatty-acid derivatives, derivatives containing tertiary amine groups, emulsifiers, special soaps, cosmetics and textiles and fibers (HSDB 1988). It also is used in chromatography in chemistry and biochemistry laboratories (DEAE is useful as an ion-exchange matrix; DEAE-cellulose columns are used for purification of proteins and DNA, and DEAE-silica for phospholipid separations). In other industries DEAE is used in some antirust compositions and in textile softeners (Hawley 1977; HSDB 1988). It is also used widely as a steam additive in large buildings requiring humidifiers.

Carcinogenicity

DEAE was not mutagenic or clastogenic in a variety of in vitro and in vivo assays.
The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for 2- diethylaminoethanol is 2 ppm (9.6mg/m3) with a notation for skin absorption.

環境運命予測

DEAE, when compared with other amino alcohols, was observed to be biologically undecomposable in an experiment using activated sludge (HSDB 1988).

代謝

The absorption of DEAE (administered orally as DEAE acid malate or 'Cerebrol') in healthy adult rats is very rapid, reaching a peak plasma level in 30 min (Bismut et al 1986). The biological half-life is 3.5 h with 39% of the excreted product appearing in the urine after 48 h (Bismut et al 1986). In an earlier study, Schulte et al (1972) demonstrated that in rats, following a single oral dose, excretion occurs mainly through the kidneys with 37-59% being eliminated in the first 24 h. After 48 h, elimination was independent of dose. The brain and spinal cord showed the highest concentration after 7 d. Metabolites produced were observed to be diethylaminoethanol N-oxide, diethylaminoacetic acid, and ethylaminoethanol.

2-ジエチルアミノエタノール 上流と下流の製品情報

原材料

準備製品


2-ジエチルアミノエタノール 生産企業

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100-37-8(2-ジエチルアミノエタノール)キーワード:


  • 100-37-8
  • β-Diethylaminoethyl alcohol
  • 2-DIETHYLAMINOETHANOL,REAGENT
  • Dietyleneglycol
  • 1,2-DIETHYLAMINOETHANOL
  • 2-DIETHYLAMINOETHANE
  • Diethylethanolamin
  • 2-(DIETHYLAMINO)-ETHANOL 99+%
  • 2-diethylaminoethanol N,N-diethylethanolamine
  • 2-DIETHYLAMINOETHANOL extrapure
  • N,N-Diethylethanolamine, 99+%
  • Ethanol, 2-(diethylamino)-
  • 2-(Diethylamino)etha
  • N,N-Diethylethanolamine (2-Hydroxyethyl)diethylamine
  • N,N-Diethyletholamine
  • DEEA
  • N,N-DIETHYLETHANOLAMINE, A PRODUCT OF ATOFINA EUROPE 99,5+%
  • 2-(DIETHYLAMINO)ETHANOL (N,N-DIETHYLETHA NOLAMIN)
  • N,N-DIETHYLETHANOLAMINE, 99.5+%
  • Rotec A.O.
  • 2-DiethylaminoethanolForSynthesis
  • Di-EthylEthanolamine(Deea)
  • 2-ChloroethanolGr
  • 100-37-8
  • 2 - Diethyl Amino Ethanol 100-37-8
  • N-Diethylethanolamine
  • 2-(Diethylamino)ethyl alcohol
  • 2-(N,N-Diethylamino)ethanol
  • 2-Hydroxytriethylamine
  • beta-(Diethylamino)ethanol
  • beta-(Diethylamino)ethyl alcohol
  • 2-ジエチルアミノエタノール
  • 2-ヒドロキシエチルジエチルアミン
  • デヒダサル
  • 2-(ジエチルアミノ)エタノール
  • 2-(N,N-ジエチルアミノ)エタノール
  • デハイダサル
  • ジエチルエタノールアミン
  • N,N-ジエチルエタノールアミン
  • N,N-ジエチルエタノルアミン
  • N,Nジエチルエタノルアミン
  • (2-ヒドロキシエチル)ジエチルアミン
  • 2‐(ジエチルアミノ)エタノール
  • 2‐ジエチルアミノエタノール
  • 2 - ジエチルアミノエタノール
  • 2-(ジエチルアミノ)エタノ-ル
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