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디메티콘 MSDS

Dimethicone

디메티콘 C화학적 특성, 용도, 생산

순도시험

  (1) 비중 : 이 품목의 비중은 0.96～1.02이어야 한다.

  (2) 굴절률 : 이 품목 20g을 정밀히 달아 헥산 100mL를 가한 후 3시간 동안 분당 200회 왕복 진동시킨 후 10,000rpm에서 30분간 원심분리한다. 상등액을 위한 다음 침전시키기 위해 헥산 50mL를 가하여 잘 분산시킨 후 원심분리한다. 상등액을 합한 후 감압하에서 50∼60℃ 수욕상에서 가온하여 헥산을 증발시킨 다음 105℃에서 1시간 건조한 것을 시험용액으로 하여 굴절률을 측정한다. 추출규소유의 굴절률은 1.400∼1.410이어야 한다.

  (3) 점도 : (2)의 굴절률 시험에서 얻은 시험용액을 25℃에서 점도시험법 중 1법 모세관 점도측정법에 따라 시험할 때, 100∼1,100 센티스토오크스이어야 한다.

  (4) 이산화규소 : 위 (2)에서 추출한 다음의 잔류물을 약 100℃에서 1시간 건조할 때, 그 양은 2.25g 이하이어야 한다(15% 이하).

  (5) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

  (6) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.

  (7) 수은 : 이 품목을 수은시험법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.

확인시험

  이 품목 100mg을 백금도가니에 넣고 황산 및 질산 수방울로 적신 다음 강열하면 흰 연기를 발생하면서 탄다. 이 흰 연기에 차가운 유리판을 갖다 대면 유리판의 표면에 분말이 부착한다. 이를 모아서 백금도가니에 넣고 수산화나트륨 3g을 가하여 녹이고 식힌 다음 물 50mL를 가하여 녹여서 여과한 다음, 그 여액 1방울 및 몰리브덴산암모늄시액 1방울을 여과지위에 적가하고 다시 벤지딘시액 1방울을 적가한 다음 암모니아의 증기에 접촉시키면 청색을 나타낸다.

화학적 성질

Dimethicones are clear, colorless liquids available in various viscosities. Dimethicone is a fluid mixture of fully methylated linear siloxane polymers end-blocked with trimethylsiloxy units. Methicone is a linear monomethyl polysiloxane. Dimethicone are safe as used in cosmetic formulations, vulcanization.

용도

dimethicone is a form of silicone used to give products lubricity, slip, and good feel. It can also serve as a formulation defoamer and help reduce the feeling of greasiness that some creams leave on the skin immediately upon application. In addition, dimethicone is reported to protect the skin against moisture loss when used in larger quantities. It improves product flow and spreadability. In combination with other ingredients, dimethicone becomes a good waterproofing material for sunscreen emulsions, and helps reduce the greasiness often seen in high-SPF preparations.

정의

ChEBI: A polydimethylsiloxane macromolecule, composed of dimethylsiloxane repeating units.

생산 방법

Dimethicone isapoly (dimethylsiloxane) obtained by hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane. The hydrolysis products contain active silanol groups through which condensation polymerization proceeds. By varying the proportions of chlorotrimethylsilane, which acts as a chain terminator, silicones of varying molecular weight may be prepared. Different grades of dimethicone are produced that may be distinguished by a number placed after the name indicating the nominal viscosity. For example, ABIL 20 (Evonik Goldschmidt UK Ltd) has a nominal kinematic viscosity of 18–22mm2/s (18–22cSt).

Indications

Silicone (dimethicone) ointments are excellent water-protective agents because they have an extremely low surface tension and penetrate crevices in the skin to form a plastic-like barrier. Further, they are nontoxic, inert, stable, and water repellent. As such, they are useful as barrier creams in industry or wherever constant or frequent exposure to aqueous compounds is a problem. They will not, however, protect well against solvents, oils, or dusts.

Pharmaceutical Applications

Dimethicones of various viscosities are widely used in cosmetic and pharmaceutical formulations. In topical oil-in-water emulsions dimethicone is added to the oil phase as an antifoaming agent. Dimethicone is hydrophobic and is also widely used in topical barrier preparations. Therapeutically, dimethicone may be used with simethicone in oral pharmaceutical formulations used in the treatment of flatulence. Dimethicone is also used to form a waterrepellent film on glass containers.

Safety

Dimethicone is generally regarded as a relatively nontoxic and nonirritant material although it can cause temporary irritation to the eyes. In pharmaceutical formulations it may be used in oral and topical preparations. Dimethicones are also used extensively in cosmetic formulations and in certain food applications.
The WHO has set a tentative estimated acceptable daily intake of dimethicone with a relative molecular mass in the range of 200–300 at up to 1.5mg/kg body-weight.
Injection of silicones into tissues may cause granulomatous reactions. Accidental intravascular injection has been associated with fatalities.

저장

Dimethicones should be stored in an airtight container in a cool, dry, place; they are stable to heat and are resistant to most chemical substances although they are affected by strong acids. Thin films of dimethicone may be sterilized by dry heat for at least 2 hours at 160°C. Sterilization of large quantities of dimethicone by steam autoclaving is notrecommended since excesswater diffuses intothe fluid causing it to become hazy. However, thin films may be sterilized by this method. Gamma irradiation may also be used to sterilize dimethicone. Gamma irradiation can, however, cause crosslinking with a consequent increase in the viscosity of fluids.

Regulatory Status

Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets, topical creams,emulsions,lotions,and transdermal preparations).Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

디메티콘 준비 용품 및 원자재

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디메티콘 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd	510-85010237	overseamarketing@alphahi-tech.com	CHINA	41	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5988	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-13102810335	admin@hbsaisier.cn	China	747	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	893	58
Hangzhou Bayee Chemical Co., Ltd.	0086-571-86990109	rachelhoo@bayeechem.com	China	104	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60

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