2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E 구조식 이미지
카스 번호:
141286-78-4
상품명:
2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
동의어(영문):
PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors;2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide;Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-;2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
CBNumber:
CB0972925
분자식:
C16H16F2N2O4S2
포뮬러 무게:
402.44
MOL 파일:
141286-78-4.mol
MSDS 파일:
SDS

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E 속성

끓는 점
617.6±65.0 °C(Predicted)
밀도
1.47±0.1 g/cm3(Predicted)
저장 조건
protect from light
용해도
DMSO: >20mg/mL
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
10.44±0.40(Predicted)
색상
하얀색
InChIKey
GTACSIONMHMRPD-UHFFFAOYSA-N

안전

WGK 독일 3

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E C화학적 특성, 용도, 생산

용도

PEPA is an allosteric potentiator of AMPA desensitization.

생물학적 활성

Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.

Biochem/physiol Actions

2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E 준비 용품 및 원자재

원자재

준비 용품


2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E 공급 업체

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