2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E C화학적 특성, 용도, 생산
용도
PEPA is an allosteric potentiator of AMPA desensitization.
생물학적 활성
Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.
Biochem/physiol Actions
2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.
2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E 준비 용품 및 원자재