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Ethyl (3-chlorobenzoyl)acetate

Ethyl (3-chlorobenzoyl)acetate 구조식 이미지

카스 번호:: 33167-21-4

상품명:: Ethyl (3-chlorobenzoyl)acetate

동의어(영문):: ETHYL (3-CHLOROBENZOYL)ACETATE;Ethyl 2-(3-chlorobenzoyl)acetate;Ethyl (3-chlorobenzoyl)acetate >=97%;Ethyl 3-chloro-β-oxobenzenepropanoate;2-[(3-chlorophenyl)-oxomethyl]butanoate;Ethyl (3-chlorobenzoyl)acetate;ETHYL 3-(3-CHLOROPHENYL)-3-OXOPROPANOATE;3-Chloro--oxobenzenepropanoic acid ethyl ester;3-(3-chlorophenyl)-3-oxopropanoic acid ethyl ester;Benzenepropanoic acid, 3-chloro-β-oxo-, ethyl ester

CBNumber:: CB1359370

분자식:: C11H11ClO3

포뮬러 무게:: 226.66

MOL 파일:: 33167-21-4.mol

속성

안전

용도

공급 업체 88

Ethyl (3-chlorobenzoyl)acetate 속성

끓는 점: 257-258 °C (lit.)

밀도: 1.213 g/mL at 25 °C (lit.)

굴절률: n20/D 1.5460(lit.)

인화점: >230 °F

저장 조건: Sealed in dry,Room Temperature

산도 계수 (pKa): 9.91±0.46(Predicted)

CAS 데이터베이스: 33167-21-4(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

WGK 독일	3

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P321	(…) 처치를 하시오.
P332+P313	피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P362	오염된 의복을 벗고 세척 후에 재사용하기

Ethyl (3-chlorobenzoyl)acetate C화학적 특성, 용도, 생산

용도

Reagent / reactant involved in:• ;Oxidative cross-coupling via dioxygen activation with indoles1• ;Chlorination and hydrosilylation for synthesis of α-hydroxy β-amino acid derivatives2• ;Precursor for substrates for chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water3• ;Intramolecular cyclization for synthesis of dihydrofurans4• ;Rate acceleration of Michael reactions5• ;Cerium ammonium nitrate-mediated oxidative coupling6

Synthesis

141.6 g of diethyl carbonate was dissolved in 1000 mL of a 1:1 ethanol-tetrahydrofuran (THF) solution, and 12.4 g of catalyst 1 Amberlite IRA-400 was added while stirring. The mixture was then heated up to 45 °C. In a separate container, 154.5 g of m-chloroacetophenone was dissolved in 1000 mL of the above-mentioned ethanol-THF mixed solvent. The addition of m-chloroacetophenone was completed within 1 hour, and stirring was continued for 6 hours. The mixture was then filtered. The filtrate was combined and the majority of the solvent was evaporated. 1500 mL of water was added to the remaining solution while stirring. The solution was then subjected to CH2Cl2 extraction, followed by washing with saturated saline until the solution reached a neutral pH. The resulting solution was dried with anhydrous MgSO4, filtered, and the solvent was evaporated. Finally, the resulting residue was distilled under reduced pressure to obtain a colorless oily liquid known as Ethyl (3-chlorobenzoyl)acetate.
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

Ethyl (3-chlorobenzoyl)acetate 준비 용품 및 원자재

원자재

에틸알코올 3-Chlorobenzoyl chloride 3-클로로벤조 산 클로로아세토페논(3-) 디에틸 카보네이트 Ethyl potassium malonate 에틸브로모아세트산

준비 용품

Ethyl (3-chlorobenzoyl)acetate 공급 업체

글로벌( 88)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Gubang New Materail Technology Co. LTD	21-51317962 +8618721305404	16728589@qq.com	CHINA	272	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503259 +86-19930503259	cherry@crovellbio.com	China	18456	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Ethyl (3-chlorobenzoyl)acetate 관련 검색:

Ethyl (3-chlorobenzoyl)acetate 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER,ETHYL 3-(4-CHLOROPHENYL)-3-OXOPROPANOATE ethyl 3-(2,5-dichlorophenyl)-3-oxopropanoate 2,4,5-TRICHLORO-BETA-OXO-BENZENEPROPANOIC ACID ETHYL ESTER 7,8-DICHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Ethyl 3-(3,5-dichlorophenyl)-3-oxopropanoate ETHYL 3-OXO-3-(2,3,4-TRICHLOROPHENYL)PROPANOATE ETHYL (3-CHLORO-5-FLUOROBENZOYL)ACETATE 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER AKOS MSC-0295 AKOS 90068 RARECHEM AL BI 0740 SALOR-INT L136042-1EA RARECHEM AL BI 0440 RARECHEM AL BI 0586 RARECHEM AL BI 0716 3-(3-CHLORO-PHENYL)-2-CYANO-3-OXO-PROPIONIC ACID ETHYL ESTER