PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem

PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem 구조식 이미지
카스 번호:
1229246-07-4
상품명:
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
동의어(영문):
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem;2,4-Thiazolidinedione, 5-[[2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-5-bromophenyl]methylene]-
CBNumber:
CB14814000
분자식:
C19H10BrF6NO3S
포뮬러 무게:
526.25
MOL 파일:
1229246-07-4.mol
MSDS 파일:
SDS

PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem 속성

밀도
1.681±0.06 g/cm3(Predicted)
산도 계수 (pKa)
7.03±0.20(Predicted)

안전

PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem C화학적 특성, 용도, 생산

일반 설명

A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 μM, respectively), but not that of LAR even at concentrations as high as 100 μM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).

PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem 준비 용품 및 원자재

원자재

준비 용품


PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem 공급 업체

글로벌( 2)공급 업체
공급자 전화 이메일 국가 제품 수 이점
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