PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem 속성
밀도
1.681±0.06 g/cm3(Predicted)
산도 계수 (pKa)
7.03±0.20(Predicted)
안전
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 μM, respectively), but not that of LAR even at concentrations as high as 100 μM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem 공급 업체
