4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
|
|
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 속성
- 녹는점
- 39.0 to 43.0 °C
- 끓는 점
- 331℃
- 밀도
- 1.31
- 인화점
- 154℃
- 용해도
- 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- powder to lump
- 색상
- White to Yellow to Green
- 안정성
- 흡습성, 수분 민감성
- InChI
- InChI=1S/C9H3F3N2S/c10-9(11,12)8-3-7(14-5-15)2-1-6(8)4-13/h1-3H
- InChIKey
- TYXKOMAQTWRDCR-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(N=C=S)C=C1C(F)(F)F
- CAS 데이터베이스
- 143782-23-4
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 2929100090 |
|---|
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile C화학적 특성, 용도, 생산
용도
4-Isothiocyanoyl-2-(trifluoromethyl)benzonitrile is a reagent used to synthesize thioimidazolinone compounds and is a potential anti-prostate cancer drug. It is also used as an intermediate of enzalutamide.Synthesis
4-Amino-2-trifluoromethylbenzonitrile, (2.23 g, 12 mmol) was added portionwise over15 minutes into the well-stirred heterogeneous mixture of thiophosgene (1 ml, 13 mmol) in water (22 ml) at room temperature. Stirring was continued for an additional 1 h. The reaction medium was extracted with chloroform (3 x 15 ml). The combined organic phase was dried over MgSO4 and evaporated to dryness under reduced pressure to yield desired product, 4-isothiocyanato-2-trifluoromethylbenzonitrile, (Ia), as brownish solid and was used as such for the next step (2.72 g, 11.9 mmol, 99%).
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 준비 용품 및 원자재
원자재
준비 용품
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 공급 업체
글로벌( 410)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Innopharm Industrial Co., Ltd. | +86-21-59960785 +86-17701845089 |
sales@hoyaopharm.com | China | 261 | 58 |
| AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 |
gjpu@astatech.com.cn | China | 308 | 58 |
| Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 13606544505 |
lucy@verychem.com | China | 1001 | 58 |
| SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | +86-0531-69954981 +8615666777973 |
dwyane.wang@boyuanpharm.com | China | 211 | 58 |
| Suzhou Chukai Pharma Tech Co.,Ltd | +8615062531973 |
2279973922@qq.com | China | 224 | 58 |
| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 |
mayan@famobiotech.com;sales@famobiotech.com | China | 503 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 |
da@zhongda-biotech.com | China | 248 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 |
linda@zhongda-biotech.com | China | 204 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 관련 검색:
네오펜틸 글리콜 사이플루트린 페닐 클로로티오노폼에이트 클로로카본일설페닐 클로라이드
FLUCYTHRINATE
2,4-DICHLOROPHENYL CHLOROTHIOFORMATE
3,5-DIMETHYLPHENYL CHLOROTHIOFORMATE
PENTAFLUOROPHENYL CHLOROTHIONOFORMATE
1,4-PHENYLENE DIISOTHIOCYANATE
o-5,6,7,8-Tetrahydro-2-naphtylthiochloroformate
2-BROMO-4-FLUOROPHENYL CHLOROTHIOFORMATE
4-(trifluoromethoxy)phenyl chlorothioformate
methyl 4-(chlorocarbonothioyloxy)benzoate
4-CHLOROPHENYL CHLOROTHIONOFORMATE
Enzalutamide Impurity 7
4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-
4-amino-2-fluoro-N-methylbenzamide
4-Bromo-2-fluoro-N-methylbenzamide