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4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione 구조식 이미지
카스 번호:
865854-05-3
상품명:
4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
동의어(영문):
CS-596;NP031112;NP-031112;NP 031112;Tideglusib;Destructible;IUSIB(NP0311120);Tideglusib fandachem;Tideglusib(NP-031112);TIDEGLUSIB;NP-12;NP031112
CBNumber:
CB22589642
분자식:
C19H14N2O2S
포뮬러 무게:
334.39
MOL 파일:
865854-05-3.mol

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione 속성

끓는 점
511.3±43.0 °C(Predicted)
밀도
1.393
저장 조건
2-8°C
용해도
DMSO: >15mg/mL
물리적 상태
powder
산도 계수 (pKa)
-1.51±0.20(Predicted)
색상
white to beige
InChIKey
PMJIHLSCWIDGMD-UHFFFAOYSA-N

안전

WGK 독일 3

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione C화학적 특성, 용도, 생산

용도

Tideglusib is used in the treatment of brain atrophy, and movement disorder issues.

주요 응용

Tideglusib is used in the treatment of brain atrophy, and movement disorder issues.
As a reagent, Tideglusib has been used:
as a reference compound in ADP-GloTM Kinase assay
as an allosteric inhibitor of GSK-3β to study its effects on myocardial remodeling and angiogenesis
as a differentiation agent (specifically a glycogen synthase kinase (GSK)-3β inhibitor) to convert fibroblast cells into octamer-binding transcription factor-4 (OCT4)+ and vascular endothelial growth factor receptor-2 (VEGFR-2/fetal liver kinase-1 (FLK1)+ cells.

생물학적 활성

Tideglusib, also known as NP031112 or NP-12, is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3), an important kinase studied in stem cell research and neurodegenerative diseases. It is currently in clinical trials for Alzheimer′s disease and Progressive Supranuclear Palsy (PSP). Tideglusib reduces phosphorylation of the tau protein and the accumulation of amyloid plaques, reduces hippocampal and entorhinal cortex neuron loss and improves spatial memory deficits. It has also shown neuroprotective and anti-inflammatory activity in a variety of animal models.

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione 준비 용품 및 원자재

원자재

준비 용품


4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione 공급 업체

글로벌( 125)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Shaanxi Dideu Medichem Co. Ltd
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029-88380327 1015@dideu.com CHINA 3994 58
Wuhan Nutra Biotechnology Co.,Ltd
+86-177-8639-4783
catherine@nutrabiotechchem.com China 298 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com China 9165 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26781 60
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione 관련 검색:

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